Augmented Growth Hormone Secretion and Stat3 Phosphorylation in an Aryl Hydrocarbon Receptor Interacting Protein (AIP)-Disrupted Somatotroph Cell Line

Aryl hydrocarbon receptor interacting protein (AIP) is thought to be a tumor suppressor gene, as indicated by a mutational analysis of pituitary somatotroph adenomas. However, the physiological significance of AIP inactivation in somatotroph cells remains unclear. Using CRISPR/Cas9, we identified a...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0164131-e0164131
Hauptverfasser:	Fukuda, Takashi, Tanaka, Tomoko, Hamaguchi, Yuriko, Kawanami, Takako, Nomiyama, Takashi, Yanase, Toshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - pathology Analysis Animals Aromatic compounds Biology and Life Sciences Cell Line Cell Proliferation CRISPR Deactivation Gene Silencing Genetic aspects Growth hormone Growth Hormone - secretion Growth Hormone-Secreting Pituitary Adenoma - pathology Growth hormones Hydrocarbons Inactivation Insulin Insulin resistance Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kinases Medicine and Health Sciences Mice Mice, Inbred BALB C Mutation Neoplasm Transplantation Phosphorylation Pituitary Rats Research and Analysis Methods Rho Guanine Nucleotide Exchange Factors - metabolism Rodents Secretion Somatostatin Somatotrophs - cytology Somatotrophs - metabolism Somatotrophs - transplantation Somatotropin Stat3 protein STAT3 Transcription Factor - metabolism Statistics Tumor suppressor genes Tumors Up-Regulation Xenografts
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