Inhibition of NET Release Fails to Reduce Adipose Tissue Inflammation in Mice

Obesity-associated diseases such as Type 2 diabetes, liver disease and cardiovascular diseases are profoundly mediated by low-grade chronic inflammation of the adipose tissue. Recently, the importance of neutrophils and neutrophil-derived myeloperoxidase and neutrophil elastase on the induction of i...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0163922-e0163922
Hauptverfasser:	Braster, Quinte, Silvestre Roig, Carlos, Hartwig, Helene, Beckers, Linda, den Toom, Myrthe, Döring, Yvonne, Daemen, Mat J, Lutgens, Esther, Soehnlein, Oliver
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adipose Tissue - drug effects Adipose Tissue - metabolism Analysis Animals Arginine Arginine deiminase Atherosclerosis B cells Biochemistry Biology and Life Sciences Body fat Cardiovascular diseases Cell activation Citrulline Cytometry Deoxyribonucleic acid Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diet Diet, High-Fat - adverse effects Disease Models, Animal Disease prevention DNA Elastase Extracellular Traps - drug effects Flow cytometry Glucose Glucose tolerance Heart diseases High fat diet House mouse Infiltration Inflammation Inflammation - metabolism Inhibition Insulin Insulin Resistance Leukocytes Leukocytes (neutrophilic) Liver Liver - drug effects Liver - metabolism Liver diseases Lupus Medicine and Health Sciences Mice Mice, Inbred C57BL Neutrophils Obesity Obesity - chemically induced Obesity - complications Obesity - metabolism Ornithine - analogs & derivatives Ornithine - pharmacology Pathogenesis Pathology Peroxidase Protein-arginine deiminase Proteins Research and Analysis Methods Rodents Type 2 diabetes White blood cells
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