Image Restoration and Analysis of Influenza Virions Binding to Membrane Receptors Reveal Adhesion-Strengthening Kinetics

With the development of single-particle tracking (SPT) microscopy and host membrane mimics called supported lipid bilayers (SLBs), stochastic virus-membrane binding interactions can be studied in depth while maintaining control over host receptor type and concentration. However, several experimental...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0163437-e0163437
Hauptverfasser:	Lee, Donald W, Hsu, Hung-Lun, Bacon, Kaitlyn B, Daniel, Susan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adhesion Adhesive bonding Adhesive strength Algorithms Assaying Binding Biology and Life Sciences Bonding strength Cell Line Data analysis Engineering Engineering and Technology Experimental design Fluorescence Fluorescent dyes Fluorescent Dyes - chemistry Fluorescent indicators Glycolipids Host-Pathogen Interactions - genetics Humans Image analysis Image processing Image restoration Influenza Influenza A virus - isolation & purification Influenza A virus - metabolism Influenza, Human - diagnosis Influenza, Human - metabolism Influenza, Human - virology Kinetics Lipid bilayers Lipid Bilayers - chemistry Lipid Bilayers - metabolism Lipids Medicine and Health Sciences Membrane lipids Microscopy Microscopy, Fluorescence Noise Orthomyxoviridae Particle tracking Photobleaching Physical Sciences Plant lipids Proteins Quantum dots Receptors Receptors, Cytoplasmic and Nuclear - metabolism Research and Analysis Methods Resonance Signal to noise ratio Stochasticity Studies Surface Plasmon Resonance Viral infections Virion - isolation & purification Virion - pathogenicity Virions Virus Attachment Viruses
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