Effect of Polyaryl Hydrocarbons on Cytotoxicity in Monocytic Cells: Potential Role of Cytochromes P450 and Oxidative Stress Pathways

Benzo(a)pyrene (BaP), naphthalene (NPh), phenanthrene (Phe), benzo(a)antharacene (BeA), and benzo(b)fluoranthene (BeF) are known carcinogenic polyaryl hydrocarbons (PAHs) present in cigarette smoke. This study was designed to examine the relative effect of these constituents on the cytotoxicity of m...

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Veröffentlicht in:	PloS one 2016-09, Vol.11 (9), p.e0163827
Hauptverfasser:	Ranjit, Sabina, Midde, Narasimha M, Sinha, Namita, Patters, Benjamin J, Rahman, Mohammad A, Cory, Theodore J, Rao, P S S, Kumar, Santosh
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Antioxidants (Nutrients) Apoptosis Benzo(a)pyrene Biology and Life Sciences Carcinogens Caspase Caspase-3 Catalase Cell cycle Cigarette smoke Cigarettes Cleavage Cytochrome Cytochrome P-450 Cytochrome P450 Cytochromes Cytochromes P450 Cytotoxicity Deoxyribonucleic acid DNA Enzymes Fluoranthene Gene expression HIV Human immunodeficiency virus Hydrocarbons Lung cancer Medicine and Health Sciences Metabolism Metabolites Monocytes Naphthalene Nicotine Oxidative stress Oxygen Pharmaceutical sciences Phenanthrene Polycyclic aromatic hydrocarbons Pyrene Reactive oxygen species Research and Analysis Methods RNA Rodents Smoke Smoking Studies Superoxide dismutase Superoxides Tobacco Toxicity Toxicology
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