Pharmacodynamic Impact of Carboxylesterase 1 Gene Variants in Patients with Congestive Heart Failure Treated with Angiotensin-Converting Enzyme Inhibitors

Variation in the carboxylesterase 1 gene (CES1) may contribute to the efficacy of ACEIs. Accordingly, we examined the impact of CES1 variants on plasma angiotensin II (ATII)/angiotensin I (ATI) ratio in patients with congestive heart failure (CHF) that underwent ACEI dose titrations. Five of these v...

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Veröffentlicht in:	PloS one 2016-09, Vol.11 (9), p.e0163341-e0163341
Hauptverfasser:	Nelveg-Kristensen, Karl Emil, Bie, Peter, Ferrero, Laura, Bjerre, Ditte, Bruun, Niels E, Egfjord, Martin, Rasmussen, Henrik B, Hansen, Peter R
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Angiotensin Angiotensin converting enzyme inhibitors Angiotensin I Angiotensin II Angiotensins Binding sites Biology and Life Sciences Carboxylesterase Cardiology Cardiovascular disease Care and treatment Confidence intervals Congestive heart failure Consortia Copy number Diuretics Drug dosages Enzyme inhibitors Enzymes Gene expression Genes Genetic aspects Genotypes Heart failure Hospitals Immunoglobulins Medicine and Health Sciences Mental health Metabolism Metabolites Patients Peptidyl-dipeptidase A Pharmacodynamics Pharmacology Psychiatry RNA polymerase Systematic review Titration Transcription Transcription (Genetics) Variance analysis Variation
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