Normal Development and Function of T Cells in Proline Rich 7 (Prr7) Deficient Mice

Transmembrane adaptor proteins (TRAPs) are important organisers for the transduction of immunoreceptor-mediated signals. Prr7 is a TRAP that regulates T cell receptor (TCR) signalling and potently induces cell death when overexpressed in human Jurkat T cells. Whether endogenous Prr7 has a similar fu...

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Veröffentlicht in:	PloS one 2016-09, Vol.11 (9), p.e0162863-e0162863
Hauptverfasser:	Hrdinka, Matous, Sudan, Kritika, Just, Sissy, Drobek, Ales, Stepanek, Ondrej, Schlüter, Dirk, Reinhold, Dirk, Jordan, Bryen A, Gintschel, Patricia, Schraven, Burkhart, Kreutz, Michael R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapter proteins Adaptor proteins Biology and Life Sciences CD4 antigen CD69 antigen Cell activation Cell death Cell migration Experimental allergic encephalomyelitis Immune response Immune system Immunology Listeria Listeria monocytogenes Lymphatic system Lymphocytes Lymphocytes B Lymphocytes T Medical research Medicine and Health Sciences Mice Multiple sclerosis Natural killer cells Neurobiology Neurodegeneration Neurosciences Phenotypes Proline Proteins Research and Analysis Methods Signal transduction Signaling Subpopulations T cell receptors T-cell receptor Thymus
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