COMT Val158Met Polymorphism Modulates Huntington's Disease Progression

Little is known about the genetic factors modulating the progression of Huntington's disease (HD). Dopamine levels are affected in HD and modulate executive functions, the main cognitive disorder of HD. We investigated whether the Val158Met polymorphism of the catechol-O-methyltransferase (COMT...

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Veröffentlicht in:	PloS one 2016-09, Vol.11 (9), p.e0161106-e0161106
Hauptverfasser:	de Diego-Balaguer, Ruth, Schramm, Catherine, Rebeix, Isabelle, Dupoux, Emmanuel, Durr, Alexandra, Brice, Alexis, Charles, Perrine, Cleret de Langavant, Laurent, Youssov, Katia, Verny, Christophe, Damotte, Vincent, Azulay, Jean-Philippe, Goizet, Cyril, Simonin, Clémence, Tranchant, Christine, Maison, Patrick, Rialland, Amandine, Schmitz, David, Jacquemot, Charlotte, Fontaine, Bertrand, Bachoud-Lévi, Anne-Catherine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Age Alleles Alzheimer's disease Biology and Life Sciences Brain research Catechol Catechol O-methyltransferase Clinical trials Cognició Cognition Cognitive ability Cognitive science Cognitive tasks Corea de Huntington Cytosine Dementia Demència Discriminant analysis Dopamine Frontal lobe Gene polymorphism Genes Genetic factors Genetics Guanine Homozygotes Human genetics Human health and pathology Huntingtin Huntington's chorea Huntington's disease Huntingtons disease Life Sciences Lòbul frontal Malalties del sistema nerviós Medical research Medicine and Health Sciences Methyltransferase Nervous system diseases Neurology Polyglutamine Polymorphism Psychiatry Psychology Social Sciences Trinucleotide repeats
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