Endoplasmic Reticulum Stress Links Oxidative Stress to Impaired Pancreatic Beta-Cell Function Caused by Human Oxidized LDL

Elevated plasma concentration of the pro-atherogenic oxidized low density lipoprotein cholesterol (LDL) triggers adverse effects in pancreatic beta-cells and is associated with type 2 diabetes. Here, we investigated whether the endoplasmic reticulum (ER) stress is a key player coupling oxidative str...

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Veröffentlicht in:	PloS one 2016-09, Vol.11 (9), p.e0163046-e0163046
Hauptverfasser:	Plaisance, Valérie, Brajkovic, Saška, Tenenbaum, Mathie, Favre, Dimitri, Ezanno, Hélène, Bonnefond, Amélie, Bonner, Caroline, Gmyr, Valéry, Kerr-Conte, Julie, Gauthier, Benoit R, Widmann, Christian, Waeber, Gérard, Pattou, François, Froguel, Philippe, Abderrahmani, Amar
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - administration & dosage Activating Transcription Factor 6 - metabolism Activation Animals Antioxidants Antioxidants - administration & dosage Apoptosis Beta cells Biology and Life Sciences Biomarkers - metabolism Butyric acid Cell death Cell Line Cholesterol Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Disease Endoplasmic reticulum Endoplasmic Reticulum Stress Endoribonucleases - metabolism Humans Hydrogen Hydrogen peroxide Hydrogen Peroxide - administration & dosage Inositol Insulin Insulin - metabolism Internal medicine Islets of Langerhans - metabolism Islets of Langerhans - pathology Islets of Langerhans - physiopathology Kinases Lipoproteins (low density) Lipoproteins, LDL - physiology Low density lipoprotein Low density lipoproteins Markers Medicine Medicine and Health Sciences Metabolism Mice Molecular biology Oxidation Oxidative Stress Pancreas Pancreatic beta cells Protein-Serine-Threonine Kinases - metabolism Proteins Rodents Saturated fatty acids Systematic review Type 2 diabetes
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