Insufficient Evidence for Rare Activation of Latent HIV in the Absence of Reservoir-Reducing Interventions
Funding: This work was supported by National Institutes of Health DP5OD019851, T15LM007079, R01GM117591, R01AI043222; Martin Delaney CARE and DARE Collaboratories (National Institutes of Health AI096113 and U19AI096109); Johns Hopkins Center for AIDS Research P30AI094189; Harvard University Center f...
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| Veröffentlicht in: | PLoS pathogens 2016-08, Vol.12 (8), p.e1005679-e1005679 |
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| creator | Hill, Alison L Rosenbloom, Daniel I S Siliciano, Janet D Siliciano, Robert F |
| description | Funding: This work was supported by National Institutes of Health DP5OD019851, T15LM007079, R01GM117591, R01AI043222; Martin Delaney CARE and DARE Collaboratories (National Institutes of Health AI096113 and U19AI096109); Johns Hopkins Center for AIDS Research P30AI094189; Harvard University Center for AIDS Research P30AI060354; Howard Hughes Medical Institute; and the Bill and Melinda Gates Foundation. Using maximum likelihood estimation, we infer that an interstrain standard deviation in growth rate of 0.09/day can explain the observed clone ratios (dotted red line). Pinkevych et al. acknowledge this point about latency reduction as well, and we hope that this discussion can spur much-needed experimental and analytical work into understanding the rate at which latently infected cells activate and fuel viral replication. |
| doi_str_mv | 10.1371/journal.ppat.1005679 |
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Using maximum likelihood estimation, we infer that an interstrain standard deviation in growth rate of 0.09/day can explain the observed clone ratios (dotted red line). Pinkevych et al. acknowledge this point about latency reduction as well, and we hope that this discussion can spur much-needed experimental and analytical work into understanding the rate at which latently infected cells activate and fuel viral replication.</description><identifier>ISSN: 1553-7374</identifier><identifier>ISSN: 1553-7366</identifier><identifier>EISSN: 1553-7374</identifier><identifier>DOI: 10.1371/journal.ppat.1005679</identifier><identifier>PMID: 27560936</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acquired immune deficiency syndrome ; AIDS ; Biology and Life Sciences ; Care and treatment ; Development and progression ; Drug Resistance ; Engineering and Technology ; Formal Comment ; Genetic Variation ; Growth rate ; Highly active antiretroviral therapy ; HIV ; HIV infections ; HIV-1 ; Human immunodeficiency virus ; Medical research ; Medicine and Health Sciences ; Patient outcomes ; Physical Sciences ; Population ; Research and Analysis Methods ; Standard deviation ; Studies ; Virulence (Microbiology) ; Virus Latency</subject><ispartof>PLoS pathogens, 2016-08, Vol.12 (8), p.e1005679-e1005679</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Hill AL, Rosenbloom DIS, Siliciano JD, Siliciano RF (2016) Insufficient Evidence for Rare Activation of Latent HIV in the Absence of Reservoir-Reducing Interventions. PLoS Pathog 12(8): e1005679. doi:10.1371/journal.ppat.1005679</rights><rights>2016 Hill et al 2016 Hill et al</rights><rights>2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Hill AL, Rosenbloom DIS, Siliciano JD, Siliciano RF (2016) Insufficient Evidence for Rare Activation of Latent HIV in the Absence of Reservoir-Reducing Interventions. 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Using maximum likelihood estimation, we infer that an interstrain standard deviation in growth rate of 0.09/day can explain the observed clone ratios (dotted red line). Pinkevych et al. acknowledge this point about latency reduction as well, and we hope that this discussion can spur much-needed experimental and analytical work into understanding the rate at which latently infected cells activate and fuel viral replication.</description><subject>Acquired immune deficiency syndrome</subject><subject>AIDS</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Development and progression</subject><subject>Drug Resistance</subject><subject>Engineering and Technology</subject><subject>Formal Comment</subject><subject>Genetic Variation</subject><subject>Growth rate</subject><subject>Highly active antiretroviral therapy</subject><subject>HIV</subject><subject>HIV infections</subject><subject>HIV-1</subject><subject>Human immunodeficiency virus</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Patient outcomes</subject><subject>Physical Sciences</subject><subject>Population</subject><subject>Research and Analysis Methods</subject><subject>Standard deviation</subject><subject>Studies</subject><subject>Virulence (Microbiology)</subject><subject>Virus Latency</subject><issn>1553-7374</issn><issn>1553-7366</issn><issn>1553-7374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqVkktv1DAUhSMEog_4BwgisSmLGfyKnWyQRlWhkUYgDY-t5Tg3U48y9tR2RvDvcTpp1UHdoCwc3fudY9-rk2VvMJpjKvDHjRu8Vf18t1NxjhEquKieZae4KOhMUMGeP_o_yc5C2CDEMMX8ZXZCRMFRRflptqltGLrOaAM25ld704LVkHfO5yvlIV_oaPYqGmdz1-VLFUfsuv6VG5vHm9Rvwp0gNVcQwO-d8bMVtIM2dp3XNqZSkiR9eJW96FQf4PV0nmc_P1_9uLyeLb99qS8Xy5nmHMcZK3FTAGICVEsx1ZpCyRBhois1bRkwxBRqCO54B4RQ3ZRINJprQRJRNRU9z94dfHe9C3JaU5C4JIiUhKGRqA9E69RG7rzZKv9HOmXkXcH5tVQ-Gt2DFKTULWcMIcwZbbmCBjgmAE3BGlLx5PVpum1ottDqNKxX_ZHpcceaG7l2e8mqqsJsNLiYDLy7HSBEuTVBQ98rC24Y352okhRifPf7f9Cnp5uotUoDGNu5dK8eTeWCiYqRlAqRqPkTVPpa2BrtLHQm1Y8EH44EiYnwO67VEIKsv6_-g_16zLIDq70LwUP3sDuM5Jj0-yHlmHQ5JT3J3j7e-4PoPtr0L6y3-Rg</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Hill, Alison L</creator><creator>Rosenbloom, Daniel I S</creator><creator>Siliciano, Janet D</creator><creator>Siliciano, Robert F</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-6583-3623</orcidid></search><sort><creationdate>20160801</creationdate><title>Insufficient Evidence for Rare Activation of Latent HIV in the Absence of Reservoir-Reducing Interventions</title><author>Hill, Alison L ; 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Martin Delaney CARE and DARE Collaboratories (National Institutes of Health AI096113 and U19AI096109); Johns Hopkins Center for AIDS Research P30AI094189; Harvard University Center for AIDS Research P30AI060354; Howard Hughes Medical Institute; and the Bill and Melinda Gates Foundation. Using maximum likelihood estimation, we infer that an interstrain standard deviation in growth rate of 0.09/day can explain the observed clone ratios (dotted red line). Pinkevych et al. acknowledge this point about latency reduction as well, and we hope that this discussion can spur much-needed experimental and analytical work into understanding the rate at which latently infected cells activate and fuel viral replication.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27560936</pmid><doi>10.1371/journal.ppat.1005679</doi><orcidid>https://orcid.org/0000-0002-6583-3623</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acquired immune deficiency syndrome AIDS Biology and Life Sciences Care and treatment Development and progression Drug Resistance Engineering and Technology Formal Comment Genetic Variation Growth rate Highly active antiretroviral therapy HIV HIV infections HIV-1 Human immunodeficiency virus Medical research Medicine and Health Sciences Patient outcomes Physical Sciences Population Research and Analysis Methods Standard deviation Studies Virulence (Microbiology) Virus Latency |
| title | Insufficient Evidence for Rare Activation of Latent HIV in the Absence of Reservoir-Reducing Interventions |
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