Association between the Presence of Autoantibodies Targeting Ficolin-3 and Active Nephritis in Patients with Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of multiple autoantibodies. Antibodies against Ficolin-3 were previously identified in the sera of some SLE patients, but their prevalence and significance have not been yet investigated. The aims of t...
Gespeichert in:
| Veröffentlicht in: | PloS one 2016-09, Vol.11 (9), p.e0160879-e0160879 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0160879 |
|---|---|
| container_issue | 9 |
| container_start_page | e0160879 |
| container_title | PloS one |
| container_volume | 11 |
| creator | Plawecki, Maëlle Lheritier, Elise Clavarino, Giovanna Jourde-Chiche, Noémie Ouili, Saber Paul, Stéphane Gout, Evelyne Sarrot-Reynauld, Françoise Bardin, Nathalie Boëlle, Pierre-Yves Chiche, Laurent Bouillet, Laurence Thielens, Nicole M Cesbron, Jean-Yves Dumestre-Pérard, Chantal |
| description | Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of multiple autoantibodies. Antibodies against Ficolin-3 were previously identified in the sera of some SLE patients, but their prevalence and significance have not been yet investigated. The aims of this study were to determine the prevalence of anti-ficolin-3 antibodies among SLE patients and to investigate their potential as diagnostic and/or prognostic biomarkers in SLE. In this retrospective study, sera from SLE patients (n = 165) were selected from a preexisting declared biological collection. Samples from healthy controls (n = 48) were matched with SLE sera. Disease activity was determined according to the SLEDAI score. Anti-ficolin-3, anti-dsDNA and anti-C1q antibodies levels were measured in sera by ELISA. First, a highly significant difference was found in the anti-ficolin-3 levels between SLE patients and healthy subjects. Anti-ficolin-3 antibodies were detected as positive in 56 of 165 (34%) SLE patients. The titer of anti-ficolin-3 antibodies was correlated with the SLEDAI score (r = 0.38, p |
| doi_str_mv | 10.1371/journal.pone.0160879 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1819911956</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A470941208</galeid><doaj_id>oai_doaj_org_article_e832b9e9c94149cab851a38306e266b6</doaj_id><sourcerecordid>A470941208</sourcerecordid><originalsourceid>FETCH-LOGICAL-c759t-1ca96f4b6a6233549c3cfa21b435288f7fdc5bae6817710c97483e78c05e826e3</originalsourceid><addsrcrecordid>eNqNk11PFDEUhidGI4j-A6NNTIxc7NqPmX7cmGwICMlGiKC3Tad7Zrdktl2mHZCf4L-24y6EJVyQXkxz5jnvad-eUxTvCR4TJsjXy9B33rTjVfAwxoRjKdSLYpcoRkecYvbywX6neBPjJcYVk5y_Lnao4IwoSXaLv5MYg3UmueBRDekGwKO0AHTWQQRvAYUGTfoUjE-uDjMHEV2Ybg7J-Tk6cja0zo8YMn6GJja5a0A_YLXoXHIROY_OsjL4FNGNSwt0fhsTLJ1F037VR3TY3eZSS5NC7OPb4lVj2gjvNt-94tfR4cXB8Wh6-v3kYDIdWVGpNCLWKN6UNTecMlaVyjLbGErqklVUykY0M1vVBrgkQhBslSglAyEtrkBSDmyv-LjWXbUh6o2LURNJlCJEVTwTJ2tiFsylXnVuabpbHYzT_wOhm2vTJWdb0CAZrRUoq0qSj2JqWRHDJMMcKOf1oPVtU62vlzCz2YvOtFui23-8W-h5uNYVphVlIgvsrwUWj9KOJ1M9xPDQDYyya5LZL5tiXbjqISa9dNFC2xoPoR_uSIVUlJfqOSiulOBCZvTTI_Rp0zbU3GRfnG9Cvo4dRPWkFDj7Q_GgNX6Cyms2tEXu5Mbl-FbC_lZCZhL8SXPTx6hPzn8-nz39vc1-fsAuwLRpEUPbD3MQt8FyDdouxNhBc_8IBOvB-js39DCIejOIOe3Dw3e_T7qbPPYPt04tQw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1819911956</pqid></control><display><type>article</type><title>Association between the Presence of Autoantibodies Targeting Ficolin-3 and Active Nephritis in Patients with Systemic Lupus Erythematosus</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Plawecki, Maëlle ; Lheritier, Elise ; Clavarino, Giovanna ; Jourde-Chiche, Noémie ; Ouili, Saber ; Paul, Stéphane ; Gout, Evelyne ; Sarrot-Reynauld, Françoise ; Bardin, Nathalie ; Boëlle, Pierre-Yves ; Chiche, Laurent ; Bouillet, Laurence ; Thielens, Nicole M ; Cesbron, Jean-Yves ; Dumestre-Pérard, Chantal</creator><creatorcontrib>Plawecki, Maëlle ; Lheritier, Elise ; Clavarino, Giovanna ; Jourde-Chiche, Noémie ; Ouili, Saber ; Paul, Stéphane ; Gout, Evelyne ; Sarrot-Reynauld, Françoise ; Bardin, Nathalie ; Boëlle, Pierre-Yves ; Chiche, Laurent ; Bouillet, Laurence ; Thielens, Nicole M ; Cesbron, Jean-Yves ; Dumestre-Pérard, Chantal</creatorcontrib><description>Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of multiple autoantibodies. Antibodies against Ficolin-3 were previously identified in the sera of some SLE patients, but their prevalence and significance have not been yet investigated. The aims of this study were to determine the prevalence of anti-ficolin-3 antibodies among SLE patients and to investigate their potential as diagnostic and/or prognostic biomarkers in SLE. In this retrospective study, sera from SLE patients (n = 165) were selected from a preexisting declared biological collection. Samples from healthy controls (n = 48) were matched with SLE sera. Disease activity was determined according to the SLEDAI score. Anti-ficolin-3, anti-dsDNA and anti-C1q antibodies levels were measured in sera by ELISA. First, a highly significant difference was found in the anti-ficolin-3 levels between SLE patients and healthy subjects. Anti-ficolin-3 antibodies were detected as positive in 56 of 165 (34%) SLE patients. The titer of anti-ficolin-3 antibodies was correlated with the SLEDAI score (r = 0.38, p<0.0001). The presence of anti-ficolin-3 antibodies was associated with anti-C1q and anti-dsDNA antibodies. Regarding associations with clinical manifestations, the presence of active lupus nephritis was significantly associated with the presence of anti-ficolin-3 antibodies (p≤0.001). This association with renal involvement was higher with anti-ficolin-3 or anti-C1q antibodies than with other auto-antibodies. Interestingly, the combination of anti-ficolin-3 and anti-C1q antibodies demonstrated higher specificity than any other serological biomarker. These results suggest that anti-ficolin-3 antibodies could be useful for the diagnosis of active nephritis in SLE patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0160879</identifier><identifier>PMID: 27631981</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Anti-DNA antibodies ; Antibodies ; Antigens ; Arthritis ; Autoantibodies ; Autoantibodies - blood ; Autoimmune diseases ; Autoimmunity ; Biology and Life Sciences ; Biomarkers ; Biomarkers - blood ; Case-Control Studies ; Chronic conditions ; Diagnosis ; Diagnostic systems ; Disease ; Disease control ; Enzyme-linked immunosorbent assay ; Female ; Glycoproteins - immunology ; Human health and pathology ; Humans ; Immunoglobulins ; Immunology ; Kidneys ; Lectins ; Lectins - immunology ; Life Sciences ; Lupus ; Lupus nephritis ; Lupus Nephritis - immunology ; Male ; Medical research ; Medicine and Health Sciences ; Middle Aged ; Nephritis ; Patients ; Proteins ; Research and Analysis Methods ; Retrospective Studies ; Systemic lupus erythematosus ; Transplants & implants ; Urology and Nephrology</subject><ispartof>PloS one, 2016-09, Vol.11 (9), p.e0160879-e0160879</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Plawecki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Attribution</rights><rights>2016 Plawecki et al 2016 Plawecki et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c759t-1ca96f4b6a6233549c3cfa21b435288f7fdc5bae6817710c97483e78c05e826e3</citedby><cites>FETCH-LOGICAL-c759t-1ca96f4b6a6233549c3cfa21b435288f7fdc5bae6817710c97483e78c05e826e3</cites><orcidid>0000-0002-5367-8232 ; 0000-0002-8830-4273 ; 0000-0003-3680-082X ; 0000-0001-9315-1577 ; 0000-0001-8245-4767</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025237/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025237/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27631981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01371323$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Plawecki, Maëlle</creatorcontrib><creatorcontrib>Lheritier, Elise</creatorcontrib><creatorcontrib>Clavarino, Giovanna</creatorcontrib><creatorcontrib>Jourde-Chiche, Noémie</creatorcontrib><creatorcontrib>Ouili, Saber</creatorcontrib><creatorcontrib>Paul, Stéphane</creatorcontrib><creatorcontrib>Gout, Evelyne</creatorcontrib><creatorcontrib>Sarrot-Reynauld, Françoise</creatorcontrib><creatorcontrib>Bardin, Nathalie</creatorcontrib><creatorcontrib>Boëlle, Pierre-Yves</creatorcontrib><creatorcontrib>Chiche, Laurent</creatorcontrib><creatorcontrib>Bouillet, Laurence</creatorcontrib><creatorcontrib>Thielens, Nicole M</creatorcontrib><creatorcontrib>Cesbron, Jean-Yves</creatorcontrib><creatorcontrib>Dumestre-Pérard, Chantal</creatorcontrib><title>Association between the Presence of Autoantibodies Targeting Ficolin-3 and Active Nephritis in Patients with Systemic Lupus Erythematosus</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of multiple autoantibodies. Antibodies against Ficolin-3 were previously identified in the sera of some SLE patients, but their prevalence and significance have not been yet investigated. The aims of this study were to determine the prevalence of anti-ficolin-3 antibodies among SLE patients and to investigate their potential as diagnostic and/or prognostic biomarkers in SLE. In this retrospective study, sera from SLE patients (n = 165) were selected from a preexisting declared biological collection. Samples from healthy controls (n = 48) were matched with SLE sera. Disease activity was determined according to the SLEDAI score. Anti-ficolin-3, anti-dsDNA and anti-C1q antibodies levels were measured in sera by ELISA. First, a highly significant difference was found in the anti-ficolin-3 levels between SLE patients and healthy subjects. Anti-ficolin-3 antibodies were detected as positive in 56 of 165 (34%) SLE patients. The titer of anti-ficolin-3 antibodies was correlated with the SLEDAI score (r = 0.38, p<0.0001). The presence of anti-ficolin-3 antibodies was associated with anti-C1q and anti-dsDNA antibodies. Regarding associations with clinical manifestations, the presence of active lupus nephritis was significantly associated with the presence of anti-ficolin-3 antibodies (p≤0.001). This association with renal involvement was higher with anti-ficolin-3 or anti-C1q antibodies than with other auto-antibodies. Interestingly, the combination of anti-ficolin-3 and anti-C1q antibodies demonstrated higher specificity than any other serological biomarker. These results suggest that anti-ficolin-3 antibodies could be useful for the diagnosis of active nephritis in SLE patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Anti-DNA antibodies</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Arthritis</subject><subject>Autoantibodies</subject><subject>Autoantibodies - blood</subject><subject>Autoimmune diseases</subject><subject>Autoimmunity</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Chronic conditions</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Disease</subject><subject>Disease control</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Female</subject><subject>Glycoproteins - immunology</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Immunology</subject><subject>Kidneys</subject><subject>Lectins</subject><subject>Lectins - immunology</subject><subject>Life Sciences</subject><subject>Lupus</subject><subject>Lupus nephritis</subject><subject>Lupus Nephritis - immunology</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Nephritis</subject><subject>Patients</subject><subject>Proteins</subject><subject>Research and Analysis Methods</subject><subject>Retrospective Studies</subject><subject>Systemic lupus erythematosus</subject><subject>Transplants & implants</subject><subject>Urology and Nephrology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11PFDEUhidGI4j-A6NNTIxc7NqPmX7cmGwICMlGiKC3Tad7Zrdktl2mHZCf4L-24y6EJVyQXkxz5jnvad-eUxTvCR4TJsjXy9B33rTjVfAwxoRjKdSLYpcoRkecYvbywX6neBPjJcYVk5y_Lnao4IwoSXaLv5MYg3UmueBRDekGwKO0AHTWQQRvAYUGTfoUjE-uDjMHEV2Ybg7J-Tk6cja0zo8YMn6GJja5a0A_YLXoXHIROY_OsjL4FNGNSwt0fhsTLJ1F037VR3TY3eZSS5NC7OPb4lVj2gjvNt-94tfR4cXB8Wh6-v3kYDIdWVGpNCLWKN6UNTecMlaVyjLbGErqklVUykY0M1vVBrgkQhBslSglAyEtrkBSDmyv-LjWXbUh6o2LURNJlCJEVTwTJ2tiFsylXnVuabpbHYzT_wOhm2vTJWdb0CAZrRUoq0qSj2JqWRHDJMMcKOf1oPVtU62vlzCz2YvOtFui23-8W-h5uNYVphVlIgvsrwUWj9KOJ1M9xPDQDYyya5LZL5tiXbjqISa9dNFC2xoPoR_uSIVUlJfqOSiulOBCZvTTI_Rp0zbU3GRfnG9Cvo4dRPWkFDj7Q_GgNX6Cyms2tEXu5Mbl-FbC_lZCZhL8SXPTx6hPzn8-nz39vc1-fsAuwLRpEUPbD3MQt8FyDdouxNhBc_8IBOvB-js39DCIejOIOe3Dw3e_T7qbPPYPt04tQw</recordid><startdate>20160915</startdate><enddate>20160915</enddate><creator>Plawecki, Maëlle</creator><creator>Lheritier, Elise</creator><creator>Clavarino, Giovanna</creator><creator>Jourde-Chiche, Noémie</creator><creator>Ouili, Saber</creator><creator>Paul, Stéphane</creator><creator>Gout, Evelyne</creator><creator>Sarrot-Reynauld, Françoise</creator><creator>Bardin, Nathalie</creator><creator>Boëlle, Pierre-Yves</creator><creator>Chiche, Laurent</creator><creator>Bouillet, Laurence</creator><creator>Thielens, Nicole M</creator><creator>Cesbron, Jean-Yves</creator><creator>Dumestre-Pérard, Chantal</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-5367-8232</orcidid><orcidid>https://orcid.org/0000-0002-8830-4273</orcidid><orcidid>https://orcid.org/0000-0003-3680-082X</orcidid><orcidid>https://orcid.org/0000-0001-9315-1577</orcidid><orcidid>https://orcid.org/0000-0001-8245-4767</orcidid></search><sort><creationdate>20160915</creationdate><title>Association between the Presence of Autoantibodies Targeting Ficolin-3 and Active Nephritis in Patients with Systemic Lupus Erythematosus</title><author>Plawecki, Maëlle ; Lheritier, Elise ; Clavarino, Giovanna ; Jourde-Chiche, Noémie ; Ouili, Saber ; Paul, Stéphane ; Gout, Evelyne ; Sarrot-Reynauld, Françoise ; Bardin, Nathalie ; Boëlle, Pierre-Yves ; Chiche, Laurent ; Bouillet, Laurence ; Thielens, Nicole M ; Cesbron, Jean-Yves ; Dumestre-Pérard, Chantal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c759t-1ca96f4b6a6233549c3cfa21b435288f7fdc5bae6817710c97483e78c05e826e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anti-DNA antibodies</topic><topic>Antibodies</topic><topic>Antigens</topic><topic>Arthritis</topic><topic>Autoantibodies</topic><topic>Autoantibodies - blood</topic><topic>Autoimmune diseases</topic><topic>Autoimmunity</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Chronic conditions</topic><topic>Diagnosis</topic><topic>Diagnostic systems</topic><topic>Disease</topic><topic>Disease control</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Female</topic><topic>Glycoproteins - immunology</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Immunology</topic><topic>Kidneys</topic><topic>Lectins</topic><topic>Lectins - immunology</topic><topic>Life Sciences</topic><topic>Lupus</topic><topic>Lupus nephritis</topic><topic>Lupus Nephritis - immunology</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Nephritis</topic><topic>Patients</topic><topic>Proteins</topic><topic>Research and Analysis Methods</topic><topic>Retrospective Studies</topic><topic>Systemic lupus erythematosus</topic><topic>Transplants & implants</topic><topic>Urology and Nephrology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Plawecki, Maëlle</creatorcontrib><creatorcontrib>Lheritier, Elise</creatorcontrib><creatorcontrib>Clavarino, Giovanna</creatorcontrib><creatorcontrib>Jourde-Chiche, Noémie</creatorcontrib><creatorcontrib>Ouili, Saber</creatorcontrib><creatorcontrib>Paul, Stéphane</creatorcontrib><creatorcontrib>Gout, Evelyne</creatorcontrib><creatorcontrib>Sarrot-Reynauld, Françoise</creatorcontrib><creatorcontrib>Bardin, Nathalie</creatorcontrib><creatorcontrib>Boëlle, Pierre-Yves</creatorcontrib><creatorcontrib>Chiche, Laurent</creatorcontrib><creatorcontrib>Bouillet, Laurence</creatorcontrib><creatorcontrib>Thielens, Nicole M</creatorcontrib><creatorcontrib>Cesbron, Jean-Yves</creatorcontrib><creatorcontrib>Dumestre-Pérard, Chantal</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Plawecki, Maëlle</au><au>Lheritier, Elise</au><au>Clavarino, Giovanna</au><au>Jourde-Chiche, Noémie</au><au>Ouili, Saber</au><au>Paul, Stéphane</au><au>Gout, Evelyne</au><au>Sarrot-Reynauld, Françoise</au><au>Bardin, Nathalie</au><au>Boëlle, Pierre-Yves</au><au>Chiche, Laurent</au><au>Bouillet, Laurence</au><au>Thielens, Nicole M</au><au>Cesbron, Jean-Yves</au><au>Dumestre-Pérard, Chantal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between the Presence of Autoantibodies Targeting Ficolin-3 and Active Nephritis in Patients with Systemic Lupus Erythematosus</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-09-15</date><risdate>2016</risdate><volume>11</volume><issue>9</issue><spage>e0160879</spage><epage>e0160879</epage><pages>e0160879-e0160879</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of multiple autoantibodies. Antibodies against Ficolin-3 were previously identified in the sera of some SLE patients, but their prevalence and significance have not been yet investigated. The aims of this study were to determine the prevalence of anti-ficolin-3 antibodies among SLE patients and to investigate their potential as diagnostic and/or prognostic biomarkers in SLE. In this retrospective study, sera from SLE patients (n = 165) were selected from a preexisting declared biological collection. Samples from healthy controls (n = 48) were matched with SLE sera. Disease activity was determined according to the SLEDAI score. Anti-ficolin-3, anti-dsDNA and anti-C1q antibodies levels were measured in sera by ELISA. First, a highly significant difference was found in the anti-ficolin-3 levels between SLE patients and healthy subjects. Anti-ficolin-3 antibodies were detected as positive in 56 of 165 (34%) SLE patients. The titer of anti-ficolin-3 antibodies was correlated with the SLEDAI score (r = 0.38, p<0.0001). The presence of anti-ficolin-3 antibodies was associated with anti-C1q and anti-dsDNA antibodies. Regarding associations with clinical manifestations, the presence of active lupus nephritis was significantly associated with the presence of anti-ficolin-3 antibodies (p≤0.001). This association with renal involvement was higher with anti-ficolin-3 or anti-C1q antibodies than with other auto-antibodies. Interestingly, the combination of anti-ficolin-3 and anti-C1q antibodies demonstrated higher specificity than any other serological biomarker. These results suggest that anti-ficolin-3 antibodies could be useful for the diagnosis of active nephritis in SLE patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27631981</pmid><doi>10.1371/journal.pone.0160879</doi><tpages>e0160879</tpages><orcidid>https://orcid.org/0000-0002-5367-8232</orcidid><orcidid>https://orcid.org/0000-0002-8830-4273</orcidid><orcidid>https://orcid.org/0000-0003-3680-082X</orcidid><orcidid>https://orcid.org/0000-0001-9315-1577</orcidid><orcidid>https://orcid.org/0000-0001-8245-4767</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-09, Vol.11 (9), p.e0160879-e0160879 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1819911956 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adult Aged Anti-DNA antibodies Antibodies Antigens Arthritis Autoantibodies Autoantibodies - blood Autoimmune diseases Autoimmunity Biology and Life Sciences Biomarkers Biomarkers - blood Case-Control Studies Chronic conditions Diagnosis Diagnostic systems Disease Disease control Enzyme-linked immunosorbent assay Female Glycoproteins - immunology Human health and pathology Humans Immunoglobulins Immunology Kidneys Lectins Lectins - immunology Life Sciences Lupus Lupus nephritis Lupus Nephritis - immunology Male Medical research Medicine and Health Sciences Middle Aged Nephritis Patients Proteins Research and Analysis Methods Retrospective Studies Systemic lupus erythematosus Transplants & implants Urology and Nephrology |
| title | Association between the Presence of Autoantibodies Targeting Ficolin-3 and Active Nephritis in Patients with Systemic Lupus Erythematosus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T14%3A43%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20the%20Presence%20of%20Autoantibodies%20Targeting%20Ficolin-3%20and%20Active%20Nephritis%20in%20Patients%20with%20Systemic%20Lupus%20Erythematosus&rft.jtitle=PloS%20one&rft.au=Plawecki,%20Ma%C3%ABlle&rft.date=2016-09-15&rft.volume=11&rft.issue=9&rft.spage=e0160879&rft.epage=e0160879&rft.pages=e0160879-e0160879&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0160879&rft_dat=%3Cgale_plos_%3EA470941208%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1819911956&rft_id=info:pmid/27631981&rft_galeid=A470941208&rft_doaj_id=oai_doaj_org_article_e832b9e9c94149cab851a38306e266b6&rfr_iscdi=true |