miR-196a Ameliorates Cytotoxicity and Cellular Phenotype in Transgenic Huntington's Disease Monkey Neural Cells

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by the expansion of polyglutamine (polyQ) tract that leads to motor, cognitive and psychiatric impairment. Currently there is no cure for HD. A transgenic HD nonhuman primate (HD-NHP) model was developed with progressiv...

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Veröffentlicht in:	PloS one 2016-09, Vol.11 (9), p.e0162788-e0162788
Hauptverfasser:	Kunkanjanawan, Tanut, Carter, Richard L, Prucha, Melinda S, Yang, Jinjing, Parnpai, Rangsun, Chan, Anthony W S
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals Animals, Genetically Modified Apoptosis Biology and Life Sciences Biomarkers Brain research Brain-derived neurotrophic factor Cells (biology) Cognitive ability Cytotoxicity Dehydrogenases Disease Models, Animal Gene expression Genes Genetic aspects Genetic engineering Genetics High definition television Humans Huntington Disease - pathology Huntington's disease Huntingtons disease Medical research Medicine Medicine and Health Sciences MicroRNAs - physiology Mitochondria Mitochondria - metabolism Nervous system diseases Neural stem cells Neural Stem Cells - metabolism Neurodegenerative diseases Neurosciences Oxidative stress Pathogenesis Phenotype Polyglutamine Primates Progenitor cells Research and Analysis Methods Rodents Stem cells Studies Toxicity Trinucleotide repeat diseases
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