Clinical Significance of Pre- and Post-Transplant BAFF Levels in Kidney Transplant Recipients
It is well known that pre-transplant B cell activating factor (BAFF) levels are associated with the development of de novo anti-HLA antibodies and antibody mediated rejection post-transplant. However, the clinical significance of BAFF values at allograft rejection has not been determined. In this st...
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| creator | Min, Ji Won Kim, Kyoung Woon Kim, Bo-Mi Doh, Kyoung Chan Choi, Min Seok Choi, Bum Soon Park, Cheol Whee Yang, Chul Woo Kim, Yong-Soo Oh, Eun-Jee Chung, Byung Ha |
| description | It is well known that pre-transplant B cell activating factor (BAFF) levels are associated with the development of de novo anti-HLA antibodies and antibody mediated rejection post-transplant. However, the clinical significance of BAFF values at allograft rejection has not been determined. In this study, we investigated the clinical significance of pre-transplant BAFF level as well as post-transplant BAFF levels measured when indication biopsy was done. We checked for anti-HLA antibodies in 115 kidney transplant recipients who required allograft biopsy due to an increase in serum creatinine. With the same serum specimen, we measured BAFF levels, and in 78 of these patients, pre-transplant BAFF and anti-HLA antibody levels were detected as well. Patients in each group were divided into tertiles according to BAFF levels. We investigated the relationship between BAFF levels and the occurrence of anti-HLA antibodies. Pre-transplant BAFF levels showed significant association with pre-transplant sensitization, and also with early rejection (Tertile 3, 26.9% vs. Tertile 1, 11.5%; P |
| doi_str_mv | 10.1371/journal.pone.0162964 |
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However, the clinical significance of BAFF values at allograft rejection has not been determined. In this study, we investigated the clinical significance of pre-transplant BAFF level as well as post-transplant BAFF levels measured when indication biopsy was done. We checked for anti-HLA antibodies in 115 kidney transplant recipients who required allograft biopsy due to an increase in serum creatinine. With the same serum specimen, we measured BAFF levels, and in 78 of these patients, pre-transplant BAFF and anti-HLA antibody levels were detected as well. Patients in each group were divided into tertiles according to BAFF levels. We investigated the relationship between BAFF levels and the occurrence of anti-HLA antibodies. Pre-transplant BAFF levels showed significant association with pre-transplant sensitization, and also with early rejection (Tertile 3, 26.9% vs. Tertile 1, 11.5%; P<0.05). Post-transplant BAFF levels showed significant association with pre-transplant sensitization, but did not show association with anti-HLA antibodies and positive donor-specific antibodies at the time of biopsy. We did not find any association between post-transplant BAFF levels and allograft biopsy results, Banff scores and microvascular inflammation scores. In conclusion, pre-transplant BAFF levels are associated with pre-transplant sensitization and are useful in predicting allograft rejection. But post-transplant BAFF levels measured at the time of indication biopsy are not associated with the appearance of de novo HLA-DSA, allograft rejection, biopsy findings and other allograft outcomes.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0162964</identifier><identifier>PMID: 27631619</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Antibodies ; Antigens ; B cells ; B-Cell Activating Factor - blood ; Biology and Life Sciences ; Biopsy ; Blood groups ; BLyS protein ; Clinical outcomes ; Clinical significance ; Creatinine ; Cytokines ; Disease ; Female ; Graft Rejection ; Graft Survival ; Histocompatibility antigen HLA ; Hospitals ; Humans ; Immunoglobulins ; Indication ; Internal medicine ; Kidney Transplantation ; Kidney transplants ; Lupus ; Lymphocytes B ; Male ; Medical research ; Medicine ; Medicine and Health Sciences ; Microvasculature ; Middle Aged ; Nephrology ; Organ transplant recipients ; Patients ; Rejection ; Research and Analysis Methods ; Studies ; Transplants & implants ; Tumor necrosis factor-TNF</subject><ispartof>PloS one, 2016-09, Vol.11 (9), p.e0162964-e0162964</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Min et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Min et al 2016 Min et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-e620a9f91cd4903bcc7c45b4ff7dde3920b256d1f9ef898a286bb841547692153</citedby><cites>FETCH-LOGICAL-c725t-e620a9f91cd4903bcc7c45b4ff7dde3920b256d1f9ef898a286bb841547692153</cites><orcidid>0000-0003-0048-5717</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025051/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025051/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23865,27923,27924,53790,53792,79371,79372</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27631619$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Stepkowski, Stanislaw</contributor><creatorcontrib>Min, Ji Won</creatorcontrib><creatorcontrib>Kim, Kyoung Woon</creatorcontrib><creatorcontrib>Kim, Bo-Mi</creatorcontrib><creatorcontrib>Doh, Kyoung Chan</creatorcontrib><creatorcontrib>Choi, Min Seok</creatorcontrib><creatorcontrib>Choi, Bum Soon</creatorcontrib><creatorcontrib>Park, Cheol Whee</creatorcontrib><creatorcontrib>Yang, Chul Woo</creatorcontrib><creatorcontrib>Kim, Yong-Soo</creatorcontrib><creatorcontrib>Oh, Eun-Jee</creatorcontrib><creatorcontrib>Chung, Byung Ha</creatorcontrib><title>Clinical Significance of Pre- and Post-Transplant BAFF Levels in Kidney Transplant Recipients</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>It is well known that pre-transplant B cell activating factor (BAFF) levels are associated with the development of de novo anti-HLA antibodies and antibody mediated rejection post-transplant. However, the clinical significance of BAFF values at allograft rejection has not been determined. In this study, we investigated the clinical significance of pre-transplant BAFF level as well as post-transplant BAFF levels measured when indication biopsy was done. We checked for anti-HLA antibodies in 115 kidney transplant recipients who required allograft biopsy due to an increase in serum creatinine. With the same serum specimen, we measured BAFF levels, and in 78 of these patients, pre-transplant BAFF and anti-HLA antibody levels were detected as well. Patients in each group were divided into tertiles according to BAFF levels. We investigated the relationship between BAFF levels and the occurrence of anti-HLA antibodies. Pre-transplant BAFF levels showed significant association with pre-transplant sensitization, and also with early rejection (Tertile 3, 26.9% vs. Tertile 1, 11.5%; P<0.05). Post-transplant BAFF levels showed significant association with pre-transplant sensitization, but did not show association with anti-HLA antibodies and positive donor-specific antibodies at the time of biopsy. We did not find any association between post-transplant BAFF levels and allograft biopsy results, Banff scores and microvascular inflammation scores. In conclusion, pre-transplant BAFF levels are associated with pre-transplant sensitization and are useful in predicting allograft rejection. But post-transplant BAFF levels measured at the time of indication biopsy are not associated with the appearance of de novo HLA-DSA, allograft rejection, biopsy findings and other allograft outcomes.</description><subject>Adult</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>B cells</subject><subject>B-Cell Activating Factor - blood</subject><subject>Biology and Life Sciences</subject><subject>Biopsy</subject><subject>Blood groups</subject><subject>BLyS protein</subject><subject>Clinical outcomes</subject><subject>Clinical significance</subject><subject>Creatinine</subject><subject>Cytokines</subject><subject>Disease</subject><subject>Female</subject><subject>Graft Rejection</subject><subject>Graft Survival</subject><subject>Histocompatibility antigen HLA</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Indication</subject><subject>Internal medicine</subject><subject>Kidney Transplantation</subject><subject>Kidney transplants</subject><subject>Lupus</subject><subject>Lymphocytes B</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Microvasculature</subject><subject>Middle Aged</subject><subject>Nephrology</subject><subject>Organ transplant recipients</subject><subject>Patients</subject><subject>Rejection</subject><subject>Research and Analysis Methods</subject><subject>Studies</subject><subject>Transplants & implants</subject><subject>Tumor necrosis 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Significance of Pre- and Post-Transplant BAFF Levels in Kidney Transplant Recipients</title><author>Min, Ji Won ; Kim, Kyoung Woon ; Kim, Bo-Mi ; Doh, Kyoung Chan ; Choi, Min Seok ; Choi, Bum Soon ; Park, Cheol Whee ; Yang, Chul Woo ; Kim, Yong-Soo ; Oh, Eun-Jee ; Chung, Byung Ha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c725t-e620a9f91cd4903bcc7c45b4ff7dde3920b256d1f9ef898a286bb841547692153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Antibodies</topic><topic>Antigens</topic><topic>B cells</topic><topic>B-Cell Activating Factor - blood</topic><topic>Biology and Life Sciences</topic><topic>Biopsy</topic><topic>Blood groups</topic><topic>BLyS protein</topic><topic>Clinical outcomes</topic><topic>Clinical significance</topic><topic>Creatinine</topic><topic>Cytokines</topic><topic>Disease</topic><topic>Female</topic><topic>Graft Rejection</topic><topic>Graft Survival</topic><topic>Histocompatibility antigen HLA</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Indication</topic><topic>Internal medicine</topic><topic>Kidney Transplantation</topic><topic>Kidney transplants</topic><topic>Lupus</topic><topic>Lymphocytes B</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Microvasculature</topic><topic>Middle Aged</topic><topic>Nephrology</topic><topic>Organ transplant recipients</topic><topic>Patients</topic><topic>Rejection</topic><topic>Research and Analysis Methods</topic><topic>Studies</topic><topic>Transplants & implants</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Min, Ji Won</creatorcontrib><creatorcontrib>Kim, Kyoung Woon</creatorcontrib><creatorcontrib>Kim, Bo-Mi</creatorcontrib><creatorcontrib>Doh, 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Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Min, Ji Won</au><au>Kim, Kyoung Woon</au><au>Kim, Bo-Mi</au><au>Doh, Kyoung Chan</au><au>Choi, Min Seok</au><au>Choi, Bum Soon</au><au>Park, Cheol Whee</au><au>Yang, Chul Woo</au><au>Kim, Yong-Soo</au><au>Oh, Eun-Jee</au><au>Chung, Byung Ha</au><au>Stepkowski, Stanislaw</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Significance of Pre- and Post-Transplant BAFF Levels in Kidney Transplant Recipients</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-09-15</date><risdate>2016</risdate><volume>11</volume><issue>9</issue><spage>e0162964</spage><epage>e0162964</epage><pages>e0162964-e0162964</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>It is well known that pre-transplant B cell activating factor (BAFF) levels are associated with the development of de novo anti-HLA antibodies and antibody mediated rejection post-transplant. However, the clinical significance of BAFF values at allograft rejection has not been determined. In this study, we investigated the clinical significance of pre-transplant BAFF level as well as post-transplant BAFF levels measured when indication biopsy was done. We checked for anti-HLA antibodies in 115 kidney transplant recipients who required allograft biopsy due to an increase in serum creatinine. With the same serum specimen, we measured BAFF levels, and in 78 of these patients, pre-transplant BAFF and anti-HLA antibody levels were detected as well. Patients in each group were divided into tertiles according to BAFF levels. We investigated the relationship between BAFF levels and the occurrence of anti-HLA antibodies. Pre-transplant BAFF levels showed significant association with pre-transplant sensitization, and also with early rejection (Tertile 3, 26.9% vs. Tertile 1, 11.5%; P<0.05). Post-transplant BAFF levels showed significant association with pre-transplant sensitization, but did not show association with anti-HLA antibodies and positive donor-specific antibodies at the time of biopsy. We did not find any association between post-transplant BAFF levels and allograft biopsy results, Banff scores and microvascular inflammation scores. In conclusion, pre-transplant BAFF levels are associated with pre-transplant sensitization and are useful in predicting allograft rejection. But post-transplant BAFF levels measured at the time of indication biopsy are not associated with the appearance of de novo HLA-DSA, allograft rejection, biopsy findings and other allograft outcomes.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27631619</pmid><doi>10.1371/journal.pone.0162964</doi><tpages>e0162964</tpages><orcidid>https://orcid.org/0000-0003-0048-5717</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Antibodies Antigens B cells B-Cell Activating Factor - blood Biology and Life Sciences Biopsy Blood groups BLyS protein Clinical outcomes Clinical significance Creatinine Cytokines Disease Female Graft Rejection Graft Survival Histocompatibility antigen HLA Hospitals Humans Immunoglobulins Indication Internal medicine Kidney Transplantation Kidney transplants Lupus Lymphocytes B Male Medical research Medicine Medicine and Health Sciences Microvasculature Middle Aged Nephrology Organ transplant recipients Patients Rejection Research and Analysis Methods Studies Transplants & implants Tumor necrosis factor-TNF |
| title | Clinical Significance of Pre- and Post-Transplant BAFF Levels in Kidney Transplant Recipients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T23%3A35%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20Significance%20of%20Pre-%20and%20Post-Transplant%20BAFF%20Levels%20in%20Kidney%20Transplant%20Recipients&rft.jtitle=PloS%20one&rft.au=Min,%20Ji%20Won&rft.date=2016-09-15&rft.volume=11&rft.issue=9&rft.spage=e0162964&rft.epage=e0162964&rft.pages=e0162964-e0162964&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0162964&rft_dat=%3Cgale_plos_%3EA470941116%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1819907258&rft_id=info:pmid/27631619&rft_galeid=A470941116&rft_doaj_id=oai_doaj_org_article_2b5b795cb97a423dbe2890ed44d9680b&rfr_iscdi=true |