Effects of Diclofenac, L-NAME, L-Arginine, and Pentadecapeptide BPC 157 on Gastrointestinal, Liver, and Brain Lesions, Failed Anastomosis, and Intestinal Adaptation Deterioration in 24 Hour-Short-Bowel Rats

Stable gastric pentadecapeptide BPC 157 was previously used to ameliorate wound healing following major surgery and counteract diclofenac toxicity. To resolve the increasing early risks following major massive small bowel resectioning surgery, diclofenac combined with nitric oxide (NO) system blocka...

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Veröffentlicht in:	PloS one 2016-09, Vol.11 (9), p.e0162590
Hauptverfasser:	Lojo, Nermin, Rasic, Zarko, Zenko Sever, Anita, Kolenc, Danijela, Vukusic, Darko, Drmic, Domagoj, Zoricic, Ivan, Sever, Marko, Seiwerth, Sven, Sikiric, Predrag
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Anastomosis Anastomosis, Surgical - adverse effects Animals Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Inflammatory Agents, Non-Steroidal - pharmacology Arginine Arginine - pharmacology Biology and Life Sciences Brain Brain - drug effects Cerebellum Cerebrum Diclofenac Diclofenac - adverse effects Diclofenac - pharmacology Duodenum Edema Gastrointestinal system Gastrointestinal tract Gastrointestinal Tract - drug effects Hepatocytes Hippocampus Intestinal adaptation Intestine, Small - drug effects Intestine, Small - surgery Lesions Liver Liver - drug effects Male Medicine and Health Sciences NG-Nitroarginine methyl ester NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide Nitric-oxide synthase Nonsteroidal anti-inflammatory drugs Pathology Peptide Fragments - pharmacology Prostaglandin endoperoxide synthase Proteins - pharmacology Purkinje cells Rats Rats, Wistar Rodents Small intestine Stomach Substrates Surgery Therapy Toxicity Wound healing Wound Healing - drug effects
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