CD271+ Mesenchymal Stem Cells as a Possible Infectious Niche for Leishmania infantum

Visceral leishmaniasis (VL) is a serious and fatal disease. Therapeutic drugs are toxic and non-sterilizing. The etiological agents Leishmania infantum and Leishmania donovani cause active and asymptomatic diseases. Effective drugs to treat VL exist but unfortunately, post-treatment relapses are com...

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Veröffentlicht in:	PloS one 2016-09, Vol.11 (9), p.e0162927
Hauptverfasser:	Lopes, Carolina S, Daifalla, Nada, Das, Bikul, Dias da Silva, Valdo, Campos-Neto, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal models Animals Antigens Ataxin Biochemistry Biocompatibility Biology and Life Sciences Bone marrow Cytotoxicity Disease Models, Animal Drugs Efflux Etiology Health aspects Humans Infections Infectious diseases Intracellular Leishmania Leishmania donovani Leishmania infantum Leishmania infantum - pathogenicity Leishmaniasis Leishmaniasis, Visceral - metabolism Leishmaniasis, Visceral - parasitology Leishmaniasis, Visceral - pathology Male Medicine and Health Sciences Mesenchymal stem cells Mesenchymal Stem Cells - metabolism Mesenchymal Stem Cells - parasitology Mesenchymal Stem Cells - pathology Mesenchyme Mice Mice, Inbred C57BL Molecular biology Parasites Parasitic diseases Physiology Rabbits Receptors, Nerve Growth Factor - metabolism Research and Analysis Methods Skin & tissue grafts Stem Cell Niche Stem cell transplantation Stem cells Toxic diseases Tuberculosis Vector-borne diseases Visceral leishmaniasis
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