Muscle Activation during Gait in Children with Duchenne Muscular Dystrophy
The aim of this prospective study was to investigate changes in muscle activity during gait in children with Duchenne muscular Dystrophy (DMD). Dynamic surface electromyography recordings (EMGs) of 16 children with DMD and pathological gait were compared with those of 15 control children. The activi...
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| creator | Ropars, Juliette Lempereur, Mathieu Vuillerot, Carole Tiffreau, Vincent Peudenier, Sylviane Cuisset, Jean-Marie Pereon, Yann Leboeuf, Fabien Delporte, Ludovic Delpierre, Yannick Gross, Raphaël Brochard, Sylvain |
| description | The aim of this prospective study was to investigate changes in muscle activity during gait in children with Duchenne muscular Dystrophy (DMD). Dynamic surface electromyography recordings (EMGs) of 16 children with DMD and pathological gait were compared with those of 15 control children. The activity of the rectus femoris (RF), vastus lateralis (VL), medial hamstrings (HS), tibialis anterior (TA) and gastrocnemius soleus (GAS) muscles was recorded and analysed quantitatively and qualitatively. The overall muscle activity in the children with DMD was significantly different from that of the control group. Percentage activation amplitudes of RF, HS and TA were greater throughout the gait cycle in the children with DMD and the timing of GAS activity differed from the control children. Significantly greater muscle coactivation was found in the children with DMD. There were no significant differences between sides. Since the motor command is normal in DMD, the hyper-activity and co-contractions likely compensate for gait instability and muscle weakness, however may have negative consequences on the muscles and may increase the energy cost of gait. Simple rehabilitative strategies such as targeted physical therapies may improve stability and thus the pattern of muscle activity. |
| doi_str_mv | 10.1371/journal.pone.0161938 |
| format | Article |
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Dynamic surface electromyography recordings (EMGs) of 16 children with DMD and pathological gait were compared with those of 15 control children. The activity of the rectus femoris (RF), vastus lateralis (VL), medial hamstrings (HS), tibialis anterior (TA) and gastrocnemius soleus (GAS) muscles was recorded and analysed quantitatively and qualitatively. The overall muscle activity in the children with DMD was significantly different from that of the control group. Percentage activation amplitudes of RF, HS and TA were greater throughout the gait cycle in the children with DMD and the timing of GAS activity differed from the control children. Significantly greater muscle coactivation was found in the children with DMD. There were no significant differences between sides. Since the motor command is normal in DMD, the hyper-activity and co-contractions likely compensate for gait instability and muscle weakness, however may have negative consequences on the muscles and may increase the energy cost of gait. Simple rehabilitative strategies such as targeted physical therapies may improve stability and thus the pattern of muscle activity.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0161938</identifier><identifier>PMID: 27622734</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Activation ; Biology and Life Sciences ; Biomechanical Phenomena - physiology ; Biomechanics ; Case-Control Studies ; Cerebral palsy ; Child ; Children ; Comparative analysis ; Duchenne muscular dystrophy ; Duchenne's muscular dystrophy ; Duchenne/physiopathology ; Dystrophy ; Electromyography ; Engineering Sciences ; Gait ; Gait - physiology ; Human health and pathology ; Humans ; Injuries ; Life Sciences ; Male ; Mechanics ; Medicine and Health Sciences ; Muscle ; Muscle contraction ; Muscle function ; Muscle, Skeletal - physiopathology ; Muscles ; Muscular Dystrophy ; Muscular Dystrophy, Duchenne - physiopathology ; Pediatrics ; Physical Sciences ; Posture ; Research and Analysis Methods ; Skeletal muscle ; Skeletal/physiopathology ; Stability ; Walking</subject><ispartof>PloS one, 2016-09, Vol.11 (9), p.e0161938-e0161938</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Ropars et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Dynamic surface electromyography recordings (EMGs) of 16 children with DMD and pathological gait were compared with those of 15 control children. The activity of the rectus femoris (RF), vastus lateralis (VL), medial hamstrings (HS), tibialis anterior (TA) and gastrocnemius soleus (GAS) muscles was recorded and analysed quantitatively and qualitatively. The overall muscle activity in the children with DMD was significantly different from that of the control group. Percentage activation amplitudes of RF, HS and TA were greater throughout the gait cycle in the children with DMD and the timing of GAS activity differed from the control children. Significantly greater muscle coactivation was found in the children with DMD. There were no significant differences between sides. Since the motor command is normal in DMD, the hyper-activity and co-contractions likely compensate for gait instability and muscle weakness, however may have negative consequences on the muscles and may increase the energy cost of gait. Simple rehabilitative strategies such as targeted physical therapies may improve stability and thus the pattern of muscle activity.</description><subject>Activation</subject><subject>Biology and Life Sciences</subject><subject>Biomechanical Phenomena - physiology</subject><subject>Biomechanics</subject><subject>Case-Control Studies</subject><subject>Cerebral palsy</subject><subject>Child</subject><subject>Children</subject><subject>Comparative analysis</subject><subject>Duchenne muscular dystrophy</subject><subject>Duchenne's muscular dystrophy</subject><subject>Duchenne/physiopathology</subject><subject>Dystrophy</subject><subject>Electromyography</subject><subject>Engineering Sciences</subject><subject>Gait</subject><subject>Gait - physiology</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Injuries</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Mechanics</subject><subject>Medicine and Health Sciences</subject><subject>Muscle</subject><subject>Muscle contraction</subject><subject>Muscle function</subject><subject>Muscle, Skeletal - 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Dynamic surface electromyography recordings (EMGs) of 16 children with DMD and pathological gait were compared with those of 15 control children. The activity of the rectus femoris (RF), vastus lateralis (VL), medial hamstrings (HS), tibialis anterior (TA) and gastrocnemius soleus (GAS) muscles was recorded and analysed quantitatively and qualitatively. The overall muscle activity in the children with DMD was significantly different from that of the control group. Percentage activation amplitudes of RF, HS and TA were greater throughout the gait cycle in the children with DMD and the timing of GAS activity differed from the control children. Significantly greater muscle coactivation was found in the children with DMD. There were no significant differences between sides. Since the motor command is normal in DMD, the hyper-activity and co-contractions likely compensate for gait instability and muscle weakness, however may have negative consequences on the muscles and may increase the energy cost of gait. Simple rehabilitative strategies such as targeted physical therapies may improve stability and thus the pattern of muscle activity.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27622734</pmid><doi>10.1371/journal.pone.0161938</doi><tpages>e0161938</tpages><orcidid>https://orcid.org/0000-0003-3948-8632</orcidid><orcidid>https://orcid.org/0000-0003-4995-0202</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2016-09, Vol.11 (9), p.e0161938-e0161938 |
| issn | 1932-6203 1932-6203 |
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| subjects | Activation Biology and Life Sciences Biomechanical Phenomena - physiology Biomechanics Case-Control Studies Cerebral palsy Child Children Comparative analysis Duchenne muscular dystrophy Duchenne's muscular dystrophy Duchenne/physiopathology Dystrophy Electromyography Engineering Sciences Gait Gait - physiology Human health and pathology Humans Injuries Life Sciences Male Mechanics Medicine and Health Sciences Muscle Muscle contraction Muscle function Muscle, Skeletal - physiopathology Muscles Muscular Dystrophy Muscular Dystrophy, Duchenne - physiopathology Pediatrics Physical Sciences Posture Research and Analysis Methods Skeletal muscle Skeletal/physiopathology Stability Walking |
| title | Muscle Activation during Gait in Children with Duchenne Muscular Dystrophy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T21%3A59%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Muscle%20Activation%20during%20Gait%20in%20Children%20with%20Duchenne%20Muscular%20Dystrophy&rft.jtitle=PloS%20one&rft.au=Ropars,%20Juliette&rft.date=2016-09-13&rft.volume=11&rft.issue=9&rft.spage=e0161938&rft.epage=e0161938&rft.pages=e0161938-e0161938&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0161938&rft_dat=%3Cgale_plos_%3EA470941370%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1819118661&rft_id=info:pmid/27622734&rft_galeid=A470941370&rft_doaj_id=oai_doaj_org_article_41f09b09e30045e38d1cb6bdff3c048b&rfr_iscdi=true |