Faster DNA Repair of Ultraviolet-Induced Cyclobutane Pyrimidine Dimers and Lower Sensitivity to Apoptosis in Human Corneal Epithelial Cells than in Epidermal Keratinocytes

Absorption of UV rays by DNA generates the formation of mutagenic cyclobutane pyrimidine dimers (CPD) and pyrimidine (6-4) pyrimidone photoproducts (6-4PP). These damages are the major cause of skin cancer because in turn, they can lead to signature UV mutations. The eye is exposed to UV light, but...

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Veröffentlicht in:	PloS one 2016-09, Vol.11 (9), p.e0162212
Hauptverfasser:	Mallet, Justin D, Dorr, Marie M, Drigeard Desgarnier, Marie-Catherine, Bastien, Nathalie, Gendron, Sébastien P, Rochette, Patrick J
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - radiation effects Biology and Life Sciences Cancer Cell death Cellular stress response Comparative analysis Compounds Cornea Cyclobutane Cyclobutane pyrimidine dimers Deoxyribonucleic acid Dimers DNA DNA damage DNA Damage - radiation effects DNA Repair DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Epidermis Epithelial cells Epithelial Cells - cytology Epithelial Cells - drug effects Epithelium Epithelium, Corneal - cytology Genotoxicity Health aspects Humans Impact damage Keratinocytes Keratinocytes - cytology Keratinocytes - drug effects Medicine and Health Sciences Mutation p53 Protein Physical sciences Pyrimidine Dimers - metabolism Pyrimidine Dimers - radiation effects Repair Sensitivity Skin Skin cancer Skin diseases Stability analysis Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism U.V. radiation Ultraviolet absorption Ultraviolet radiation Ultraviolet Rays XPC protein
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