CaMKII-Mediated CREB Phosphorylation Is Involved in Ca2+-Induced BDNF mRNA Transcription and Neurite Outgrowth Promoted by Electrical Stimulation

Electrical stimulation (ES)-triggered up-regulation of brain-derived neurotrophic factor (BDNF) and neurite outgrowth in cultured rat postnatal dorsal root ganglion neurons (DRGNs) is calcium (Ca2+)-dependent. The effects of increased Ca2+ on BDNF up-regulation and neurite outgrowth remain unclear....

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Veröffentlicht in:	PloS one 2016-09, Vol.11 (9), p.e0162784-e0162784
Hauptverfasser:	Yan, Xiaodong, Liu, Juanfang, Ye, Zhengxu, Huang, Jinghui, He, Fei, Xiao, Wei, Hu, Xueyu, Luo, Zhuojing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axonogenesis Biology and Life Sciences Brain Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Ca2+/calmodulin-dependent protein kinase II Calcium Calcium - pharmacology Calcium signalling Calcium-binding protein Calcium-Calmodulin-Dependent Protein Kinase Kinase - metabolism Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Calmodulin Cyclic AMP response element-binding protein Cyclic AMP Response Element-Binding Protein - metabolism Dorsal root ganglia Electric Stimulation Electrical stimuli Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Gene expression In vivo methods and tests Intracellular Space - metabolism Kinases Laboratory animals Medicine and Health Sciences Models, Biological Neuronal Outgrowth - drug effects Neuronal Outgrowth - genetics Neurons Neurons - drug effects Neurons - metabolism Phosphorylation Phosphorylation - drug effects Protein Subunits - metabolism Proteins Rats, Sprague-Dawley Regeneration Reproducibility of Results Research and Analysis Methods RNA, Messenger - genetics RNA, Messenger - metabolism Signal transduction Stimulation Transcription Transcription, Genetic - drug effects
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