Preovulatory Aging In Vivo and In Vitro Affects Maturation Rates, Abundance of Selected Proteins, Histone Methylation Pattern and Spindle Integrity in Murine Oocytes

Delayed ovulation and delayed fertilization can lead to reduced developmental competence of the oocyte. In contrast to the consequences of postovulatory aging of the oocyte, hardly anything is known about the molecular processes occurring during oocyte maturation if ovulation is delayed (preovulator...

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Veröffentlicht in:	PloS one 2016-09, Vol.11 (9), p.e0162722-e0162722
Hauptverfasser:	Demond, Hannah, Trapphoff, Tom, Dankert, Deborah, Heiligentag, Martyna, Grümmer, Ruth, Horsthemke, Bernhard, Eichenlaub-Ritter, Ursula
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Aging Aging - metabolism Analysis Animal models Animals Biology and Life Sciences Chromosomes Chromosomes, Mammalian - metabolism Deregulation Embryogenesis Embryonic development Embryonic growth stage Epigenetics Fertilization Gene expression Gonadotropin-releasing hormone Histones - metabolism Kinases Laboratory animals Localization Lysine - metabolism Maturation Medicine and Health Sciences Metaphase Methylation Mice mRNA stability Neurohormones Oocytes Oocytes - metabolism Ovulation Protein structure Proteins Research and Analysis Methods RNA RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Rodents Shelf life Spindle Apparatus - metabolism Stem cells Transcription
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