The GSTM2 C-Terminal Domain Depresses Contractility and Ca2+ Transients in Neonatal Rat Ventricular Cardiomyocytes

The cardiac ryanodine receptor (RyR2) is an intracellular ion channel that regulates Ca2+ release from the sarcoplasmic reticulum (SR) during excitation-contraction coupling in the heart. The glutathione transferases (GSTs) are a family of phase II detoxification enzymes with additional functions in...

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Veröffentlicht in:	PloS one 2016-09, Vol.11 (9), p.e0162415-e0162415
Hauptverfasser:	Hewawasam, Ruwani P, Liu, Dan, Casarotto, Marco G, Board, Philip G, Dulhunty, Angela F
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinin Animals Animals, Newborn Arrhythmia Biology and Life Sciences Calcium (reticular) Calcium Signaling Cardiac muscle Cardiomyocytes Chromatography Detoxification Electric Stimulation Enzymes Exposure Glutathione Glutathione Transferase - chemistry Glutathione Transferase - metabolism Heart Heart diseases Heart Ventricles - metabolism Inhibition Ion channels Kinases Medical research Medicine and Health Sciences Models, Molecular Muscle contraction Musculoskeletal system Mutants Mutation Myocardial Contraction Myocytes Myocytes, Cardiac - metabolism Neonates Newborn babies Protein Conformation Protein Interaction Domains and Motifs Rats Research and Analysis Methods Rodents Ryanodine receptors Sarcoplasmic reticulum Ventricle
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