Characterization of the Mouse and Human Monoacylglycerol O-Acyltransferase 1 (Mogat1) Promoter in Human Kidney Proximal Tubule and Rat Liver Cells

Monoacylglycerol acyltransferase 1 (Mogat1) catalyzes the conversion of monoacylglycerols (MAG) to diacylglycerols (DAG), the precursor of several physiologically important lipids such as phosphatidylcholine, phosphatidylethanolamine and triacylglycerol (TAG). Expression of Mogat1 is tissue restrict...

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Veröffentlicht in:	PloS one 2016-09, Vol.11 (9), p.e0162504
Hauptverfasser:	Sankella, Shireesha, Garg, Abhimanyu, Agarwal, Anil K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferase Acyltransferases - genetics Adipose tissue Anilides - pharmacology Animals Assaying Binding sites Bioinformatics Biology and Life Sciences Blotting, Northern Caco-2 Cells Cell culture Cell Line Cell Line, Tumor Chromatin Chromatin Immunoprecipitation Computational Biology Conformation CRISPR Deoxyribonucleic acid Diabetes Diglycerides DNA Fatty acids Gene regulation Genes Genomes Hepatocytes HT29 Cells Humans Immunoprecipitation Insulin resistance Internal medicine Isoforms Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - metabolism Lecithin Lipids Liver Liver - drug effects Liver - metabolism Luciferase Mammals Medicine and Health Sciences Metabolic disorders Mice Mutagenesis Nutrition Oxazoles - pharmacology Peroxisome proliferator-activated receptors Phosphatidylcholine Phosphatidylethanolamine PPAR alpha - agonists PPAR alpha - antagonists & inhibitors PPAR alpha - metabolism Promoter Regions, Genetic - genetics Promoters Promoters (Genetics) Proteins Pyrimidines - pharmacology Rats Real-Time Polymerase Chain Reaction Reporter gene Research and Analysis Methods Rodents Stomach Studies Sulfones - pharmacology Thiazoles - pharmacology Thiazolidinediones - pharmacology Thiophenes - pharmacology Transcription Transcription factors Tyrosine - analogs & derivatives Tyrosine - pharmacology
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