Tumor-Preferential Induction of Immune Responses and Epidermal Cell Death in Actinic Keratoses by Ingenol Mebutate

The rapid and strong clinical efficacy of the first-in-class, ingenol mebutate, against actinic keratosis (AK) has resulted in its recent approval. We conducted the first comprehensive analysis of the cellular and molecular mode of action of topical ingenol mebutate 0.05% gel in both AK and uninvolv...

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Veröffentlicht in:	PloS one 2016-09, Vol.11 (9), p.e0160096-e0160096
Hauptverfasser:	Emmert, Steffen, Haenssle, Holger A, Zibert, John R, Schön, Margarete, Hald, Andreas, Hansen, Maria H, Litman, Thomas, Schön, Michael P
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Adult Analysis Apoptosis Biochemistry Biology and life sciences Biomarkers Cancer CD4 antigen CD8 antigen Cell activation Cell death Cell Death - drug effects Chemokines Cluster Analysis Dermatology Diterpenes - pharmacology Diterpenes - therapeutic use Epidermis - drug effects Epidermis - immunology Epidermis - metabolism Epidermis - pathology Gene clusters Gene Expression Gene Expression Profiling Humans Immune response Immunity Immunity, Innate Inflammation Innate immunity Intercellular adhesion molecule 1 Keratosis Keratosis, Actinic - drug therapy Keratosis, Actinic - etiology Keratosis, Actinic - metabolism Keratosis, Actinic - pathology Kinases Leukocytes (neutrophilic) Leukocytes - immunology Leukocytes - metabolism Leukocytes - pathology Lymphocytes T Macrophages Medicine and Health Sciences MicroRNA MicroRNAs MicroRNAs - genetics miRNA Mode of action Patients RNA, Messenger - genetics Skin Stem cells T cells Tumors Wounding
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