Decreased Caffeine-Induced Locomotor Activity via Microinjection of CART Peptide into the Nucleus Accumbens Is Linked to Inhibition of the pCaMKIIa-D3R Interaction

The purpose of this study was to characterize the inhibitory modulation of cocaine- and amphetamine-regulated transcript (CART) peptides, particularly with respect to the function of the D3 dopamine receptor (D3R), which is activated by its interaction with phosphorylated CaMKIIα (pCaMKIIα) in the n...

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Veröffentlicht in:	PloS one 2016-07, Vol.11 (7), p.e0159104-e0159104
Hauptverfasser:	Fu, Qiang, Zhou, Xiaoyan, Dong, Yun, Huang, Yonghong, Yang, Jianhua, Oh, Ki-Wan, Hu, Zhenzhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamines Animal behavior Animal tissues Animals Biology and Life Sciences Caffeine Caffeine - antagonists & inhibitors Caffeine - pharmacology Calcium - metabolism Calcium channels Calcium influx Calcium ions Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Cocaine Cocaine- and amphetamine-regulated transcript protein Cyclic AMP - metabolism Cyclic AMP response element-binding protein Cyclic AMP Response Element-Binding Protein - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Depolarization Dopamine Dopamine D3 receptors Gene Expression Regulation, Enzymologic - drug effects Inhibition Kinases Locomotion - drug effects Locomotor activity Male Medicine and Health Sciences Microinjection Microinjections Nerve Tissue Proteins - administration & dosage Nerve Tissue Proteins - pharmacology Neurons Neurons - cytology Neurons - drug effects Neurons - metabolism Nuclei Nucleus accumbens Nucleus Accumbens - cytology Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Oral administration Peptides Phosphoproteins - metabolism Phosphorylation Physical Sciences Protein Binding - drug effects Protein kinase A Rats Rats, Sprague-Dawley Receptors, Dopamine D3 - metabolism Research and Analysis Methods Rodents Signal transduction Signal Transduction - drug effects Signaling Transcription
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