Effect of Predatory Bacteria on Human Cell Lines
Predatory bacteria are Gram-negative bacteria that prey on other Gram-negative bacteria and have been considered as potential therapeutic agents against multi-drug resistant pathogens. In vivo animal models have demonstrated that predatory bacteria are non-toxic and non-immunogenic in rodents. In or...
Gespeichert in:
| Veröffentlicht in: | PloS one 2016-08, Vol.11 (8), p.e0161242 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 8 |
| container_start_page | e0161242 |
| container_title | PloS one |
| container_volume | 11 |
| creator | Gupta, Shilpi Tang, Chi Tran, Michael Kadouri, Daniel E |
| description | Predatory bacteria are Gram-negative bacteria that prey on other Gram-negative bacteria and have been considered as potential therapeutic agents against multi-drug resistant pathogens. In vivo animal models have demonstrated that predatory bacteria are non-toxic and non-immunogenic in rodents. In order to consider the use of predatory bacteria as live antibiotics, it is important to investigate their effect on human cells. The aim of this study was to determine the effect of Bdellovibrio bacteriovorus strains 109J and HD100, and Micavibrio aeruginosavorus strain ARL-13 on cell viability and inflammatory responses of five human cell lines, representative of clinically relevant tissues. We found that the predators were not cytotoxic to any of the human cell lines tested. Microscopic imaging showed no signs of cell detachment, as compared to predator-free cells. In comparison to an E. coli control, exposure to higher concentrations of the predators did not trigger a significant elevation of pro-inflammatory cytokines in four of the five human cell lines tested. Our work underlines the non-pathogenic attributes of predatory bacteria on human cells and highlights their potential use as live antibiotics against human pathogens. |
| doi_str_mv | 10.1371/journal.pone.0161242 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1815712608</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A462097670</galeid><doaj_id>oai_doaj_org_article_7302f72b328c4902bfc5c8c639474a80</doaj_id><sourcerecordid>A462097670</sourcerecordid><originalsourceid>FETCH-LOGICAL-c725t-1085138d54b8ba609a49ddffbfcd0be206d934dfc07ce20c6bbbc3e17a47c4e3</originalsourceid><addsrcrecordid>eNqNkluL1DAUx4so7kW_gWhBWPRhxtyaNC_COqzuwMCKLr6GNJeZDJ1mTFJxv72p012msg9SQnP5nX_OOfkXxSsI5hAz-GHr-9DJdr73nZkDSCEi6ElxCjlGM4oAfno0PynOYtwCUOGa0ufFCWIV4xzy0wJcWWtUKr0tvwajZfLhrvwkVTLBydJ35XW_k125MG1brlxn4ovimZVtNC_H_3lx-_nqdnE9W918WS4uVzPFUJVmENQVxLWuSFM3kgIuCdfa2sYqDRqDANUcE20VYCqvFG2aRmEDmSRMEYPPizcH2X3roxhrjQLWsGIQUVBnYnkgtJdbsQ9uJ8Od8NKJvxs-rIUMyanWCIYBsgw1GNWKcIByEpWqFcWcMCJrkLU-jrf1zc5oZboUZDsRnZ50biPW_peoAKCcoyzwbhQI_mdvYhI7F1VumuyM74e8EavzADyjb_9BH69upNYyF-A66_O9ahAVlyQ_KWeUDXnPH6Hyp83OqWwM6_L-JOD9JCAzyfxOa9nHKJbfv_0_e_Njyl4csRsj27SJvu2T812cguQAquBjDMY-NBkCMfj6vhti8LUYfZ3DXh8_0EPQvZHxH1P38Fs</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1815712608</pqid></control><display><type>article</type><title>Effect of Predatory Bacteria on Human Cell Lines</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS)</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Gupta, Shilpi ; Tang, Chi ; Tran, Michael ; Kadouri, Daniel E</creator><contributor>Boneca, Ivo G.</contributor><creatorcontrib>Gupta, Shilpi ; Tang, Chi ; Tran, Michael ; Kadouri, Daniel E ; Boneca, Ivo G.</creatorcontrib><description>Predatory bacteria are Gram-negative bacteria that prey on other Gram-negative bacteria and have been considered as potential therapeutic agents against multi-drug resistant pathogens. In vivo animal models have demonstrated that predatory bacteria are non-toxic and non-immunogenic in rodents. In order to consider the use of predatory bacteria as live antibiotics, it is important to investigate their effect on human cells. The aim of this study was to determine the effect of Bdellovibrio bacteriovorus strains 109J and HD100, and Micavibrio aeruginosavorus strain ARL-13 on cell viability and inflammatory responses of five human cell lines, representative of clinically relevant tissues. We found that the predators were not cytotoxic to any of the human cell lines tested. Microscopic imaging showed no signs of cell detachment, as compared to predator-free cells. In comparison to an E. coli control, exposure to higher concentrations of the predators did not trigger a significant elevation of pro-inflammatory cytokines in four of the five human cell lines tested. Our work underlines the non-pathogenic attributes of predatory bacteria on human cells and highlights their potential use as live antibiotics against human pathogens.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0161242</identifier><identifier>PMID: 27579919</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Animal models ; Animal tissues ; Antibiotics ; Bacteria ; Bdellovibrio bacteriovorus ; Bdellovibrio bacteriovorus - metabolism ; Biocompatibility ; Biology ; Biology and Life Sciences ; Biotechnology ; Cell Line ; Cell lines ; Chemical compounds ; Cytokines ; Cytotoxicity ; Dentistry ; Detachment ; Drug resistance ; E coli ; Ecology and Environmental Sciences ; Escherichia coli ; Escherichia coli - metabolism ; Escherichia coli Infections - metabolism ; Gram-negative bacteria ; Health aspects ; Human behavior ; Humans ; Immunogenicity ; Inflammation ; Inflammation - metabolism ; Inflammation - microbiology ; Medical research ; Medicine ; Medicine and Health Sciences ; Multidrug resistance ; Pathogens ; Pharmacology ; Predators ; Prey ; Research and Analysis Methods ; Rodents</subject><ispartof>PloS one, 2016-08, Vol.11 (8), p.e0161242</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Gupta et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Gupta et al 2016 Gupta et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-1085138d54b8ba609a49ddffbfcd0be206d934dfc07ce20c6bbbc3e17a47c4e3</citedby><cites>FETCH-LOGICAL-c725t-1085138d54b8ba609a49ddffbfcd0be206d934dfc07ce20c6bbbc3e17a47c4e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006992/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006992/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23865,27923,27924,53790,53792,79371,79372</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27579919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Boneca, Ivo G.</contributor><creatorcontrib>Gupta, Shilpi</creatorcontrib><creatorcontrib>Tang, Chi</creatorcontrib><creatorcontrib>Tran, Michael</creatorcontrib><creatorcontrib>Kadouri, Daniel E</creatorcontrib><title>Effect of Predatory Bacteria on Human Cell Lines</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Predatory bacteria are Gram-negative bacteria that prey on other Gram-negative bacteria and have been considered as potential therapeutic agents against multi-drug resistant pathogens. In vivo animal models have demonstrated that predatory bacteria are non-toxic and non-immunogenic in rodents. In order to consider the use of predatory bacteria as live antibiotics, it is important to investigate their effect on human cells. The aim of this study was to determine the effect of Bdellovibrio bacteriovorus strains 109J and HD100, and Micavibrio aeruginosavorus strain ARL-13 on cell viability and inflammatory responses of five human cell lines, representative of clinically relevant tissues. We found that the predators were not cytotoxic to any of the human cell lines tested. Microscopic imaging showed no signs of cell detachment, as compared to predator-free cells. In comparison to an E. coli control, exposure to higher concentrations of the predators did not trigger a significant elevation of pro-inflammatory cytokines in four of the five human cell lines tested. Our work underlines the non-pathogenic attributes of predatory bacteria on human cells and highlights their potential use as live antibiotics against human pathogens.</description><subject>Analysis</subject><subject>Animal models</subject><subject>Animal tissues</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Bdellovibrio bacteriovorus</subject><subject>Bdellovibrio bacteriovorus - metabolism</subject><subject>Biocompatibility</subject><subject>Biology</subject><subject>Biology and Life Sciences</subject><subject>Biotechnology</subject><subject>Cell Line</subject><subject>Cell lines</subject><subject>Chemical compounds</subject><subject>Cytokines</subject><subject>Cytotoxicity</subject><subject>Dentistry</subject><subject>Detachment</subject><subject>Drug resistance</subject><subject>E coli</subject><subject>Ecology and Environmental Sciences</subject><subject>Escherichia coli</subject><subject>Escherichia coli - metabolism</subject><subject>Escherichia coli Infections - metabolism</subject><subject>Gram-negative bacteria</subject><subject>Health aspects</subject><subject>Human behavior</subject><subject>Humans</subject><subject>Immunogenicity</subject><subject>Inflammation</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - microbiology</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Multidrug resistance</subject><subject>Pathogens</subject><subject>Pharmacology</subject><subject>Predators</subject><subject>Prey</subject><subject>Research and Analysis Methods</subject><subject>Rodents</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkluL1DAUx4so7kW_gWhBWPRhxtyaNC_COqzuwMCKLr6GNJeZDJ1mTFJxv72p012msg9SQnP5nX_OOfkXxSsI5hAz-GHr-9DJdr73nZkDSCEi6ElxCjlGM4oAfno0PynOYtwCUOGa0ufFCWIV4xzy0wJcWWtUKr0tvwajZfLhrvwkVTLBydJ35XW_k125MG1brlxn4ovimZVtNC_H_3lx-_nqdnE9W918WS4uVzPFUJVmENQVxLWuSFM3kgIuCdfa2sYqDRqDANUcE20VYCqvFG2aRmEDmSRMEYPPizcH2X3roxhrjQLWsGIQUVBnYnkgtJdbsQ9uJ8Od8NKJvxs-rIUMyanWCIYBsgw1GNWKcIByEpWqFcWcMCJrkLU-jrf1zc5oZboUZDsRnZ50biPW_peoAKCcoyzwbhQI_mdvYhI7F1VumuyM74e8EavzADyjb_9BH69upNYyF-A66_O9ahAVlyQ_KWeUDXnPH6Hyp83OqWwM6_L-JOD9JCAzyfxOa9nHKJbfv_0_e_Njyl4csRsj27SJvu2T812cguQAquBjDMY-NBkCMfj6vhti8LUYfZ3DXh8_0EPQvZHxH1P38Fs</recordid><startdate>20160831</startdate><enddate>20160831</enddate><creator>Gupta, Shilpi</creator><creator>Tang, Chi</creator><creator>Tran, Michael</creator><creator>Kadouri, Daniel E</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160831</creationdate><title>Effect of Predatory Bacteria on Human Cell Lines</title><author>Gupta, Shilpi ; Tang, Chi ; Tran, Michael ; Kadouri, Daniel E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c725t-1085138d54b8ba609a49ddffbfcd0be206d934dfc07ce20c6bbbc3e17a47c4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Analysis</topic><topic>Animal models</topic><topic>Animal tissues</topic><topic>Antibiotics</topic><topic>Bacteria</topic><topic>Bdellovibrio bacteriovorus</topic><topic>Bdellovibrio bacteriovorus - metabolism</topic><topic>Biocompatibility</topic><topic>Biology</topic><topic>Biology and Life Sciences</topic><topic>Biotechnology</topic><topic>Cell Line</topic><topic>Cell lines</topic><topic>Chemical compounds</topic><topic>Cytokines</topic><topic>Cytotoxicity</topic><topic>Dentistry</topic><topic>Detachment</topic><topic>Drug resistance</topic><topic>E coli</topic><topic>Ecology and Environmental Sciences</topic><topic>Escherichia coli</topic><topic>Escherichia coli - metabolism</topic><topic>Escherichia coli Infections - metabolism</topic><topic>Gram-negative bacteria</topic><topic>Health aspects</topic><topic>Human behavior</topic><topic>Humans</topic><topic>Immunogenicity</topic><topic>Inflammation</topic><topic>Inflammation - metabolism</topic><topic>Inflammation - microbiology</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Multidrug resistance</topic><topic>Pathogens</topic><topic>Pharmacology</topic><topic>Predators</topic><topic>Prey</topic><topic>Research and Analysis Methods</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gupta, Shilpi</creatorcontrib><creatorcontrib>Tang, Chi</creatorcontrib><creatorcontrib>Tran, Michael</creatorcontrib><creatorcontrib>Kadouri, Daniel E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gupta, Shilpi</au><au>Tang, Chi</au><au>Tran, Michael</au><au>Kadouri, Daniel E</au><au>Boneca, Ivo G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Predatory Bacteria on Human Cell Lines</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-08-31</date><risdate>2016</risdate><volume>11</volume><issue>8</issue><spage>e0161242</spage><pages>e0161242-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Predatory bacteria are Gram-negative bacteria that prey on other Gram-negative bacteria and have been considered as potential therapeutic agents against multi-drug resistant pathogens. In vivo animal models have demonstrated that predatory bacteria are non-toxic and non-immunogenic in rodents. In order to consider the use of predatory bacteria as live antibiotics, it is important to investigate their effect on human cells. The aim of this study was to determine the effect of Bdellovibrio bacteriovorus strains 109J and HD100, and Micavibrio aeruginosavorus strain ARL-13 on cell viability and inflammatory responses of five human cell lines, representative of clinically relevant tissues. We found that the predators were not cytotoxic to any of the human cell lines tested. Microscopic imaging showed no signs of cell detachment, as compared to predator-free cells. In comparison to an E. coli control, exposure to higher concentrations of the predators did not trigger a significant elevation of pro-inflammatory cytokines in four of the five human cell lines tested. Our work underlines the non-pathogenic attributes of predatory bacteria on human cells and highlights their potential use as live antibiotics against human pathogens.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27579919</pmid><doi>10.1371/journal.pone.0161242</doi><tpages>e0161242</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-08, Vol.11 (8), p.e0161242 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1815712608 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Analysis Animal models Animal tissues Antibiotics Bacteria Bdellovibrio bacteriovorus Bdellovibrio bacteriovorus - metabolism Biocompatibility Biology Biology and Life Sciences Biotechnology Cell Line Cell lines Chemical compounds Cytokines Cytotoxicity Dentistry Detachment Drug resistance E coli Ecology and Environmental Sciences Escherichia coli Escherichia coli - metabolism Escherichia coli Infections - metabolism Gram-negative bacteria Health aspects Human behavior Humans Immunogenicity Inflammation Inflammation - metabolism Inflammation - microbiology Medical research Medicine Medicine and Health Sciences Multidrug resistance Pathogens Pharmacology Predators Prey Research and Analysis Methods Rodents |
| title | Effect of Predatory Bacteria on Human Cell Lines |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T09%3A42%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Predatory%20Bacteria%20on%20Human%20Cell%20Lines&rft.jtitle=PloS%20one&rft.au=Gupta,%20Shilpi&rft.date=2016-08-31&rft.volume=11&rft.issue=8&rft.spage=e0161242&rft.pages=e0161242-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0161242&rft_dat=%3Cgale_plos_%3EA462097670%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1815712608&rft_id=info:pmid/27579919&rft_galeid=A462097670&rft_doaj_id=oai_doaj_org_article_7302f72b328c4902bfc5c8c639474a80&rfr_iscdi=true |