Computational Model for Tumor Oxygenation Applied to Clinical Data on Breast Tumor Hemoglobin Concentrations Suggests Vascular Dilatation and Compression

We present a computational model for trans-vascular oxygen transport in synthetic tumor and host tissue blood vessel networks, aiming at qualitatively explaining published data of optical mammography, which were obtained from 87 breast cancer patients. The data generally show average hemoglobin conc...

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Veröffentlicht in:	PloS one 2016-08, Vol.11 (8), p.e0161267-e0161267
Hauptverfasser:	Welter, Michael, Fredrich, Thierry, Rinneberg, Herbert, Rieger, Heiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Arteries Arteries - metabolism Biological Transport Biology and Life Sciences Blood Blood flow Blood levels Blood vessels Breast cancer Breast Neoplasms - blood supply Breast Neoplasms - metabolism Breast Neoplasms - pathology Capillaries - metabolism Capillary flow Cell proliferation Chemotherapy Compartments Compression Computation Computer applications Computer Simulation Extracellular matrix Female Flow characteristics Hematocrit Hemodynamics Hemoglobin Hemoglobins - metabolism Humans Hypoxia Mammary Glands, Human - blood supply Mammary Glands, Human - metabolism Mammary Glands, Human - pathology Mammography Medical imaging Medicine and Health Sciences Melanoma Metabolic rate Metabolism Models, Biological Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology NMR Nuclear magnetic resonance Oxygen Oxygen - metabolism Oxygen Consumption Oxygen demand Oxygenation Oxyhemoglobins - metabolism Permeability Physical Sciences Physics Pressure distribution Skin cancer Spatial distribution Spatial heterogeneity Stress concentration Theoretical physics Tumors Vasodilation
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