The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases

Methionine adenosyltransferases MAT I and MAT III (encoded by Mat1a) catalyze S-adenosylmethionine synthesis in normal liver. Major hepatic diseases concur with reduced levels of this essential methyl donor, which are primarily due to an expression switch from Mat1a towards Mat2a. Additional changes...

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Veröffentlicht in:	PloS one 2016-08, Vol.11 (8), p.e0161672-e0161672
Hauptverfasser:	Pérez, Claudia, Pérez-Zúñiga, Francisco J, Garrido, Francisco, Reytor, Edel, Portillo, Francisco, Pajares, María A
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Adenosylmethionine Animals Biology and Life Sciences Catalysis Cell growth Cell Line, Tumor Cercopithecus aethiops Chemical synthesis CHO Cells Cloning Coding COS Cells Cricetulus Deoxyribonucleic acid DNA DNA Methylation DNA microarrays DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Epigenesis, Genetic Gastric cancer Gene expression Gene Expression Profiling Gene Expression Regulation, Enzymologic Gene Library Genetic aspects HEK293 Cells Hepatocytes Hepatocytes - enzymology Hepatocytes - pathology Hepatology Hepatoma Humans Immunoprecipitation Isoenzymes Isoenzymes - genetics Isoenzymes - metabolism Liver Liver - enzymology Liver - pathology Liver cancer Liver diseases Localization Male Medicine and Health Sciences Methionine Methionine adenosyltransferase Methionine Adenosyltransferase - genetics Methionine Adenosyltransferase - metabolism Nuclei Nuclei (cytology) Oncogene Proteins - genetics Oncogene Proteins - metabolism Oncogenes Oxidative stress Physiological aspects Plasmids Properties Protein interaction Protein Interaction Mapping Protein-protein interactions Proteins Rats Rats, Wistar Research and Analysis Methods Risk factors Rodents S-Adenosylmethionine S-Adenosylmethionine - metabolism Stomach cancer Thyroid gland Two-Hybrid System Techniques Yeast
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