IL-33 Receptor-Expressing Regulatory T Cells Are Highly Activated, Th2 Biased and Suppress CD4 T Cell Proliferation through IL-10 and TGFβ Release

Immunomodulatory Foxp3+ regulatory T cells (Tregs) form a heterogeneous population consisting of subsets with different activation states, migratory properties and suppressive functions. Recently, expression of the IL-33 receptor ST2 was shown on Tregs in inflammatory settings. Here we report that S...

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Veröffentlicht in:	PloS one 2016-08, Vol.11 (8), p.e0161507-e0161507
Hauptverfasser:	Siede, Julia, Fröhlich, Anja, Datsi, Angeliki, Hegazy, Ahmed N, Varga, Domonkos V, Holecska, Vivien, Saito, Hirohisa, Nakae, Susumu, Löhning, Max
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animal tissues Animals Antigens Arthritis Biology and life sciences CD4 antigen Cell growth Cell Lineage - immunology Cell Proliferation Chemokine receptors Clinical medicine Cytokines Foxp3 protein GATA-3 protein GATA3 Transcription Factor - genetics GATA3 Transcription Factor - immunology Gene expression Gene Expression Regulation Genotype & phenotype Growth factors Homing Homing behavior Immunology Immunomodulation Immunophenotyping Immunoregulation Inflammation Interleukin 10 Interleukin 13 Interleukin 5 Interleukin-1 Receptor-Like 1 Protein - deficiency Interleukin-1 Receptor-Like 1 Protein - genetics Interleukin-1 Receptor-Like 1 Protein - immunology Interleukin-10 - genetics Interleukin-10 - immunology Interleukin-13 - genetics Interleukin-13 - immunology Interleukin-33 - genetics Interleukin-33 - immunology Interleukin-5 - genetics Interleukin-5 - immunology Laboratories Lymphocyte Activation Lymphocytes Lymphocytes T Lymphoid tissue Medicine Medicine and health sciences Mice Mice, Inbred C57BL Mice, Knockout Receptors Rheumatism Rheumatology Signal Transduction T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - immunology Transcription factors Transforming Growth Factor beta - genetics Transforming Growth Factor beta - immunology
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