Unsaturated Oral Fat Load Test Improves Glycemia, Insulinemia and Oxidative Stress Status in Nondiabetic Subjects with Abdominal Obesity
To evaluate the changes in glycemia, insulinemia, and oxidative stress markers during an oral fat load test in nondiabetic subjects with abdominal obesity and to analyze the association between postprandial oxidative stress markers and postprandial glucose and insulin responses. We included 20 subje...
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| creator | Martinez-Hervas, Sergio Navarro, Inmaculada Real, Jose T Artero, Ana Peiro, Marta Gonzalez-Navarro, Herminia Carmena, Rafael Ascaso, Juan F |
| description | To evaluate the changes in glycemia, insulinemia, and oxidative stress markers during an oral fat load test in nondiabetic subjects with abdominal obesity and to analyze the association between postprandial oxidative stress markers and postprandial glucose and insulin responses.
We included 20 subjects with abdominal obesity (waist circumference > 102 cm for men and > 88 cm for women) and 20 healthy lean controls (waist circumference < 102 cm for men and < 88 cm for women). After 12 hours of fasting we performed a standardized fat load test (0-8 hours) with supracal® (50 g/m2). We determined metabolic parameters, oxidized and reduced glutathione, and malondialdehyde.
In both groups, insulin, HOMA, oxidized/reduced glutathione ratio, and malondialdehyde significantly decreased in the postprandial state after the OFLT. All these parameters were significantly higher in the abdominal obesity group at baseline and during all the postprandial points, but the reduction from the baseline levels was significantly higher in the abdominal obesity group.
Unsaturated fat improves insulin resistance and oxidative stress status. It is possible that a consumption of unsaturated fat could be beneficial even in subjects with abdominal obesity in postprandial state. |
| doi_str_mv | 10.1371/journal.pone.0161400 |
| format | Article |
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We included 20 subjects with abdominal obesity (waist circumference > 102 cm for men and > 88 cm for women) and 20 healthy lean controls (waist circumference < 102 cm for men and < 88 cm for women). After 12 hours of fasting we performed a standardized fat load test (0-8 hours) with supracal® (50 g/m2). We determined metabolic parameters, oxidized and reduced glutathione, and malondialdehyde.
In both groups, insulin, HOMA, oxidized/reduced glutathione ratio, and malondialdehyde significantly decreased in the postprandial state after the OFLT. All these parameters were significantly higher in the abdominal obesity group at baseline and during all the postprandial points, but the reduction from the baseline levels was significantly higher in the abdominal obesity group.
Unsaturated fat improves insulin resistance and oxidative stress status. It is possible that a consumption of unsaturated fat could be beneficial even in subjects with abdominal obesity in postprandial state.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0161400</identifier><identifier>PMID: 27537847</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abdomen ; Adolescent ; Adult ; Aged ; Alcohol ; Analysis ; Biology and Life Sciences ; Blood glucose ; Blood Glucose - drug effects ; Cardiovascular disease ; Care and treatment ; Case-Control Studies ; Complications and side effects ; Diabetes ; Diagnosis ; Endocrinology ; Fasting ; Fat load ; Fats, Unsaturated - pharmacology ; Fatty acids ; Female ; Glutathione ; Glutathione - blood ; Glutathione - metabolism ; Hospitals ; Humans ; Hypertension ; Hypoglycemia ; Inflammation ; Insulin ; Insulin - blood ; Insulin Resistance ; Lipids ; Lipoproteins ; Male ; Malondialdehyde ; Malondialdehyde - blood ; Malondialdehyde - metabolism ; Markers ; Medicine ; Medicine and Health Sciences ; Metabolic disorders ; Middle Aged ; Nutrition ; Obesity ; Obesity, Abdominal ; Oils & fats ; Oxidation resistance ; Oxidative stress ; Oxidative Stress - drug effects ; Physical Sciences ; Postprandial Period - drug effects ; Risk factors ; Rodents ; Womens health ; Young Adult</subject><ispartof>PloS one, 2016-08, Vol.11 (8), p.e0161400-e0161400</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Martinez-Hervas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Martinez-Hervas et al 2016 Martinez-Hervas et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-ca116ad50277be198faa73c6e54ffb4dcc1956f959ece905d6683b2a875d76a3</citedby><cites>FETCH-LOGICAL-c725t-ca116ad50277be198faa73c6e54ffb4dcc1956f959ece905d6683b2a875d76a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990252/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990252/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23864,27922,27923,53789,53791,79370,79371</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27537847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Folli, Franco</contributor><creatorcontrib>Martinez-Hervas, Sergio</creatorcontrib><creatorcontrib>Navarro, Inmaculada</creatorcontrib><creatorcontrib>Real, Jose T</creatorcontrib><creatorcontrib>Artero, Ana</creatorcontrib><creatorcontrib>Peiro, Marta</creatorcontrib><creatorcontrib>Gonzalez-Navarro, Herminia</creatorcontrib><creatorcontrib>Carmena, Rafael</creatorcontrib><creatorcontrib>Ascaso, Juan F</creatorcontrib><title>Unsaturated Oral Fat Load Test Improves Glycemia, Insulinemia and Oxidative Stress Status in Nondiabetic Subjects with Abdominal Obesity</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To evaluate the changes in glycemia, insulinemia, and oxidative stress markers during an oral fat load test in nondiabetic subjects with abdominal obesity and to analyze the association between postprandial oxidative stress markers and postprandial glucose and insulin responses.
We included 20 subjects with abdominal obesity (waist circumference > 102 cm for men and > 88 cm for women) and 20 healthy lean controls (waist circumference < 102 cm for men and < 88 cm for women). After 12 hours of fasting we performed a standardized fat load test (0-8 hours) with supracal® (50 g/m2). We determined metabolic parameters, oxidized and reduced glutathione, and malondialdehyde.
In both groups, insulin, HOMA, oxidized/reduced glutathione ratio, and malondialdehyde significantly decreased in the postprandial state after the OFLT. All these parameters were significantly higher in the abdominal obesity group at baseline and during all the postprandial points, but the reduction from the baseline levels was significantly higher in the abdominal obesity group.
Unsaturated fat improves insulin resistance and oxidative stress status. It is possible that a consumption of unsaturated fat could be beneficial even in subjects with abdominal obesity in postprandial state.</description><subject>Abdomen</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Alcohol</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Blood glucose</subject><subject>Blood Glucose - drug effects</subject><subject>Cardiovascular disease</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Complications and side effects</subject><subject>Diabetes</subject><subject>Diagnosis</subject><subject>Endocrinology</subject><subject>Fasting</subject><subject>Fat load</subject><subject>Fats, Unsaturated - pharmacology</subject><subject>Fatty acids</subject><subject>Female</subject><subject>Glutathione</subject><subject>Glutathione - blood</subject><subject>Glutathione - metabolism</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypoglycemia</subject><subject>Inflammation</subject><subject>Insulin</subject><subject>Insulin - 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drug effects</topic><topic>Cardiovascular disease</topic><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Complications and side effects</topic><topic>Diabetes</topic><topic>Diagnosis</topic><topic>Endocrinology</topic><topic>Fasting</topic><topic>Fat load</topic><topic>Fats, Unsaturated - pharmacology</topic><topic>Fatty acids</topic><topic>Female</topic><topic>Glutathione</topic><topic>Glutathione - blood</topic><topic>Glutathione - metabolism</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypoglycemia</topic><topic>Inflammation</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Lipids</topic><topic>Lipoproteins</topic><topic>Male</topic><topic>Malondialdehyde</topic><topic>Malondialdehyde - blood</topic><topic>Malondialdehyde - metabolism</topic><topic>Markers</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Metabolic disorders</topic><topic>Middle Aged</topic><topic>Nutrition</topic><topic>Obesity</topic><topic>Obesity, Abdominal</topic><topic>Oils & fats</topic><topic>Oxidation resistance</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martinez-Hervas, Sergio</au><au>Navarro, Inmaculada</au><au>Real, Jose T</au><au>Artero, Ana</au><au>Peiro, Marta</au><au>Gonzalez-Navarro, Herminia</au><au>Carmena, Rafael</au><au>Ascaso, Juan F</au><au>Folli, Franco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unsaturated Oral Fat Load Test Improves Glycemia, Insulinemia and Oxidative Stress Status in Nondiabetic Subjects with Abdominal Obesity</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-08-18</date><risdate>2016</risdate><volume>11</volume><issue>8</issue><spage>e0161400</spage><epage>e0161400</epage><pages>e0161400-e0161400</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To evaluate the changes in glycemia, insulinemia, and oxidative stress markers during an oral fat load test in nondiabetic subjects with abdominal obesity and to analyze the association between postprandial oxidative stress markers and postprandial glucose and insulin responses.
We included 20 subjects with abdominal obesity (waist circumference > 102 cm for men and > 88 cm for women) and 20 healthy lean controls (waist circumference < 102 cm for men and < 88 cm for women). After 12 hours of fasting we performed a standardized fat load test (0-8 hours) with supracal® (50 g/m2). We determined metabolic parameters, oxidized and reduced glutathione, and malondialdehyde.
In both groups, insulin, HOMA, oxidized/reduced glutathione ratio, and malondialdehyde significantly decreased in the postprandial state after the OFLT. All these parameters were significantly higher in the abdominal obesity group at baseline and during all the postprandial points, but the reduction from the baseline levels was significantly higher in the abdominal obesity group.
Unsaturated fat improves insulin resistance and oxidative stress status. It is possible that a consumption of unsaturated fat could be beneficial even in subjects with abdominal obesity in postprandial state.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27537847</pmid><doi>10.1371/journal.pone.0161400</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-08, Vol.11 (8), p.e0161400-e0161400 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1812825388 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abdomen Adolescent Adult Aged Alcohol Analysis Biology and Life Sciences Blood glucose Blood Glucose - drug effects Cardiovascular disease Care and treatment Case-Control Studies Complications and side effects Diabetes Diagnosis Endocrinology Fasting Fat load Fats, Unsaturated - pharmacology Fatty acids Female Glutathione Glutathione - blood Glutathione - metabolism Hospitals Humans Hypertension Hypoglycemia Inflammation Insulin Insulin - blood Insulin Resistance Lipids Lipoproteins Male Malondialdehyde Malondialdehyde - blood Malondialdehyde - metabolism Markers Medicine Medicine and Health Sciences Metabolic disorders Middle Aged Nutrition Obesity Obesity, Abdominal Oils & fats Oxidation resistance Oxidative stress Oxidative Stress - drug effects Physical Sciences Postprandial Period - drug effects Risk factors Rodents Womens health Young Adult |
| title | Unsaturated Oral Fat Load Test Improves Glycemia, Insulinemia and Oxidative Stress Status in Nondiabetic Subjects with Abdominal Obesity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T04%3A25%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Unsaturated%20Oral%20Fat%20Load%20Test%20Improves%20Glycemia,%20Insulinemia%20and%20Oxidative%20Stress%20Status%20in%20Nondiabetic%20Subjects%20with%20Abdominal%20Obesity&rft.jtitle=PloS%20one&rft.au=Martinez-Hervas,%20Sergio&rft.date=2016-08-18&rft.volume=11&rft.issue=8&rft.spage=e0161400&rft.epage=e0161400&rft.pages=e0161400-e0161400&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0161400&rft_dat=%3Cgale_plos_%3EA461034684%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1812825388&rft_id=info:pmid/27537847&rft_galeid=A461034684&rft_doaj_id=oai_doaj_org_article_795020f54fdc45f58e21b05f0ad5c3b7&rfr_iscdi=true |