Increased Serum Levels of Oxytocin in 'Treatment Resistant Depression in Adolescents (TRDIA)' Group
'Treatment-resistant depression' is depression that does not respond to an adequate regimen of evidence-based treatment. Treatment-resistant depression frequently becomes chronic. Children with treatment-resistant depression might also develop bipolar disorder (BD). The objective of this s...
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| creator | Sasaki, Tsuyoshi Hashimoto, Kenji Oda, Yasunori Ishima, Tamaki Yakita, Madoka Kurata, Tsutomu Kunou, Masaru Takahashi, Jumpei Kamata, Yu Kimura, Atsushi Niitsu, Tomihisa Komatsu, Hideki Hasegawa, Tadashi Shiina, Akihiro Hashimoto, Tasuku Kanahara, Nobuhisa Shimizu, Eiji Iyo, Masaomi |
| description | 'Treatment-resistant depression' is depression that does not respond to an adequate regimen of evidence-based treatment. Treatment-resistant depression frequently becomes chronic. Children with treatment-resistant depression might also develop bipolar disorder (BD). The objective of this study was to determine whether serum levels of oxytocin (OXT) in treatment-resistant depression in adolescents (TRDIA) differ from non-treatment-resistant depression in adolescents (non-TRDIA) or controls. We also investigated the relationships between serum OXT levels and the clinical symptoms, severity, and familial histories of adolescent depressive patients.
We measured serum OXT levels: TRDIA (n = 10), non-TRDIA (n = 27), and age- and sex- matched, neurotypical controls (n = 25). Patients were evaluated using the Children's Depression Rating Scale-Revised (CDRS-R) and the Depression Self-Rating Scale for Children-Japanese Version (DSRS-C-J). The patients were also assessed retrospectively using the following variables: familial history of major depressive disorder and BD (1st degree or 2nd degree), history of disruptive mood dysregulation disorder, recurrent depressive disorder (RDD), history of antidepressant activation.
Serum levels of OXT among the TRDIA and non-TRDIA patients and controls differed significantly. Interestingly, the rates of a family history of BD (1st or 2nd degree), RDD and a history of antidepressant activation in our TRDIA group were significantly higher than those of the non-TRDIA group.
Serum levels of OXT may play a role in the pathophysiology of TRDIA. |
| doi_str_mv | 10.1371/journal.pone.0160767 |
| format | Article |
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We measured serum OXT levels: TRDIA (n = 10), non-TRDIA (n = 27), and age- and sex- matched, neurotypical controls (n = 25). Patients were evaluated using the Children's Depression Rating Scale-Revised (CDRS-R) and the Depression Self-Rating Scale for Children-Japanese Version (DSRS-C-J). The patients were also assessed retrospectively using the following variables: familial history of major depressive disorder and BD (1st degree or 2nd degree), history of disruptive mood dysregulation disorder, recurrent depressive disorder (RDD), history of antidepressant activation.
Serum levels of OXT among the TRDIA and non-TRDIA patients and controls differed significantly. Interestingly, the rates of a family history of BD (1st or 2nd degree), RDD and a history of antidepressant activation in our TRDIA group were significantly higher than those of the non-TRDIA group.
Serum levels of OXT may play a role in the pathophysiology of TRDIA.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0160767</identifier><identifier>PMID: 27536785</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Activation ; Adolescent ; Adolescents ; Antidepressants ; Antidepressive Agents - therapeutic use ; Biology and Life Sciences ; Bipolar disorder ; Children ; Depressive Disorder, Treatment-Resistant - blood ; Depressive Disorder, Treatment-Resistant - drug therapy ; Drug therapy ; Evidence-based medicine ; Female ; Genetics ; Health aspects ; Humans ; Male ; Measurement methods ; Medicine and Health Sciences ; Mental depression ; Mood ; Oxytocin ; Oxytocin - blood ; Patients ; People and Places ; Physiological aspects ; Psychological aspects ; Retrospective Studies ; Risk factors ; Serum levels ; Social Sciences ; Suicides & suicide attempts ; Teenagers</subject><ispartof>PloS one, 2016-08, Vol.11 (8), p.e0160767-e0160767</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Sasaki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Sasaki et al 2016 Sasaki et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c791t-2b895b568ae01e5eb5fe8f789168f3f959e3bced0768b728ba4894e4caf798433</citedby><cites>FETCH-LOGICAL-c791t-2b895b568ae01e5eb5fe8f789168f3f959e3bced0768b728ba4894e4caf798433</cites><orcidid>0000-0001-8502-6469</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990411/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990411/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27536785$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Zhang, Xiang Yang</contributor><creatorcontrib>Sasaki, Tsuyoshi</creatorcontrib><creatorcontrib>Hashimoto, Kenji</creatorcontrib><creatorcontrib>Oda, Yasunori</creatorcontrib><creatorcontrib>Ishima, Tamaki</creatorcontrib><creatorcontrib>Yakita, Madoka</creatorcontrib><creatorcontrib>Kurata, Tsutomu</creatorcontrib><creatorcontrib>Kunou, Masaru</creatorcontrib><creatorcontrib>Takahashi, Jumpei</creatorcontrib><creatorcontrib>Kamata, Yu</creatorcontrib><creatorcontrib>Kimura, Atsushi</creatorcontrib><creatorcontrib>Niitsu, Tomihisa</creatorcontrib><creatorcontrib>Komatsu, Hideki</creatorcontrib><creatorcontrib>Hasegawa, Tadashi</creatorcontrib><creatorcontrib>Shiina, Akihiro</creatorcontrib><creatorcontrib>Hashimoto, Tasuku</creatorcontrib><creatorcontrib>Kanahara, Nobuhisa</creatorcontrib><creatorcontrib>Shimizu, Eiji</creatorcontrib><creatorcontrib>Iyo, Masaomi</creatorcontrib><title>Increased Serum Levels of Oxytocin in 'Treatment Resistant Depression in Adolescents (TRDIA)' Group</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>'Treatment-resistant depression' is depression that does not respond to an adequate regimen of evidence-based treatment. Treatment-resistant depression frequently becomes chronic. Children with treatment-resistant depression might also develop bipolar disorder (BD). The objective of this study was to determine whether serum levels of oxytocin (OXT) in treatment-resistant depression in adolescents (TRDIA) differ from non-treatment-resistant depression in adolescents (non-TRDIA) or controls. We also investigated the relationships between serum OXT levels and the clinical symptoms, severity, and familial histories of adolescent depressive patients.
We measured serum OXT levels: TRDIA (n = 10), non-TRDIA (n = 27), and age- and sex- matched, neurotypical controls (n = 25). Patients were evaluated using the Children's Depression Rating Scale-Revised (CDRS-R) and the Depression Self-Rating Scale for Children-Japanese Version (DSRS-C-J). The patients were also assessed retrospectively using the following variables: familial history of major depressive disorder and BD (1st degree or 2nd degree), history of disruptive mood dysregulation disorder, recurrent depressive disorder (RDD), history of antidepressant activation.
Serum levels of OXT among the TRDIA and non-TRDIA patients and controls differed significantly. Interestingly, the rates of a family history of BD (1st or 2nd degree), RDD and a history of antidepressant activation in our TRDIA group were significantly higher than those of the non-TRDIA group.
Serum levels of OXT may play a role in the pathophysiology of TRDIA.</description><subject>Activation</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Antidepressants</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Biology and Life Sciences</subject><subject>Bipolar disorder</subject><subject>Children</subject><subject>Depressive Disorder, Treatment-Resistant - blood</subject><subject>Depressive Disorder, Treatment-Resistant - drug therapy</subject><subject>Drug therapy</subject><subject>Evidence-based medicine</subject><subject>Female</subject><subject>Genetics</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Male</subject><subject>Measurement methods</subject><subject>Medicine and Health Sciences</subject><subject>Mental depression</subject><subject>Mood</subject><subject>Oxytocin</subject><subject>Oxytocin - blood</subject><subject>Patients</subject><subject>People and 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Serum Levels of Oxytocin in 'Treatment Resistant Depression in Adolescents (TRDIA)' Group</title><author>Sasaki, Tsuyoshi ; Hashimoto, Kenji ; Oda, Yasunori ; Ishima, Tamaki ; Yakita, Madoka ; Kurata, Tsutomu ; Kunou, Masaru ; Takahashi, Jumpei ; Kamata, Yu ; Kimura, Atsushi ; Niitsu, Tomihisa ; Komatsu, Hideki ; Hasegawa, Tadashi ; Shiina, Akihiro ; Hashimoto, Tasuku ; Kanahara, Nobuhisa ; Shimizu, Eiji ; Iyo, Masaomi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c791t-2b895b568ae01e5eb5fe8f789168f3f959e3bced0768b728ba4894e4caf798433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Activation</topic><topic>Adolescent</topic><topic>Adolescents</topic><topic>Antidepressants</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Biology and Life Sciences</topic><topic>Bipolar disorder</topic><topic>Children</topic><topic>Depressive Disorder, 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Yang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Serum Levels of Oxytocin in 'Treatment Resistant Depression in Adolescents (TRDIA)' Group</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-08-18</date><risdate>2016</risdate><volume>11</volume><issue>8</issue><spage>e0160767</spage><epage>e0160767</epage><pages>e0160767-e0160767</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>'Treatment-resistant depression' is depression that does not respond to an adequate regimen of evidence-based treatment. Treatment-resistant depression frequently becomes chronic. Children with treatment-resistant depression might also develop bipolar disorder (BD). The objective of this study was to determine whether serum levels of oxytocin (OXT) in treatment-resistant depression in adolescents (TRDIA) differ from non-treatment-resistant depression in adolescents (non-TRDIA) or controls. We also investigated the relationships between serum OXT levels and the clinical symptoms, severity, and familial histories of adolescent depressive patients.
We measured serum OXT levels: TRDIA (n = 10), non-TRDIA (n = 27), and age- and sex- matched, neurotypical controls (n = 25). Patients were evaluated using the Children's Depression Rating Scale-Revised (CDRS-R) and the Depression Self-Rating Scale for Children-Japanese Version (DSRS-C-J). The patients were also assessed retrospectively using the following variables: familial history of major depressive disorder and BD (1st degree or 2nd degree), history of disruptive mood dysregulation disorder, recurrent depressive disorder (RDD), history of antidepressant activation.
Serum levels of OXT among the TRDIA and non-TRDIA patients and controls differed significantly. Interestingly, the rates of a family history of BD (1st or 2nd degree), RDD and a history of antidepressant activation in our TRDIA group were significantly higher than those of the non-TRDIA group.
Serum levels of OXT may play a role in the pathophysiology of TRDIA.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27536785</pmid><doi>10.1371/journal.pone.0160767</doi><tpages>e0160767</tpages><orcidid>https://orcid.org/0000-0001-8502-6469</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-08, Vol.11 (8), p.e0160767-e0160767 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1812823467 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Activation Adolescent Adolescents Antidepressants Antidepressive Agents - therapeutic use Biology and Life Sciences Bipolar disorder Children Depressive Disorder, Treatment-Resistant - blood Depressive Disorder, Treatment-Resistant - drug therapy Drug therapy Evidence-based medicine Female Genetics Health aspects Humans Male Measurement methods Medicine and Health Sciences Mental depression Mood Oxytocin Oxytocin - blood Patients People and Places Physiological aspects Psychological aspects Retrospective Studies Risk factors Serum levels Social Sciences Suicides & suicide attempts Teenagers |
| title | Increased Serum Levels of Oxytocin in 'Treatment Resistant Depression in Adolescents (TRDIA)' Group |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T17%3A41%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increased%20Serum%20Levels%20of%20Oxytocin%20in%20'Treatment%20Resistant%20Depression%20in%20Adolescents%20(TRDIA)'%20Group&rft.jtitle=PloS%20one&rft.au=Sasaki,%20Tsuyoshi&rft.date=2016-08-18&rft.volume=11&rft.issue=8&rft.spage=e0160767&rft.epage=e0160767&rft.pages=e0160767-e0160767&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0160767&rft_dat=%3Cgale_plos_%3EA461034643%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1812823467&rft_id=info:pmid/27536785&rft_galeid=A461034643&rft_doaj_id=oai_doaj_org_article_ab23f6116c9e4f3c8c164e054ef85193&rfr_iscdi=true |