Decoding the Regulatory Landscape of Ageing in Musculoskeletal Engineered Tissues Using Genome-Wide DNA Methylation and RNASeq

Mesenchymal stem cells (MSC) are capable of multipotent differentiation into connective tissues and as such are an attractive source for autologous cell-based regenerative medicine and tissue engineering. Epigenetic mechanisms, like DNA methylation, contribute to the changes in gene expression in ag...

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Veröffentlicht in:	PloS one 2016-08, Vol.11 (8), p.e0160517-e0160517
Hauptverfasser:	Peffers, Mandy Jayne, Goljanek-Whysall, Katarzyna, Collins, John, Fang, Yongxiang, Rushton, Michael, Loughlin, John, Proctor, Carole, Clegg, Peter David
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aging - genetics Aging - pathology Alternative Splicing Analysis Arthritis Autografts Biocompatibility Biology and life sciences Biomedical materials Cell death Cell Differentiation Cell morphology Cell Proliferation Cell survival Cells, Cultured Chondrogenesis - genetics Chronic illnesses Connective tissues Cytology Decoding Deoxyribonucleic acid Differentiation DNA DNA Methylation DNA sequencing Engineering and Technology Enrichment Epigenesis, Genetic Epigenetic inheritance Epigenetics Gene expression Gene regulation Gene Regulatory Networks Gene sequencing Genes Genetic aspects Genomes Humans Medicine and Health Sciences Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Mesenchyme Methylation Middle Aged Morphogenesis Musculoskeletal System - metabolism Musculoskeletal System - pathology Oligonucleotide Array Sequence Analysis Osteogenesis - genetics Physiological aspects Regenerative Medicine Ribonucleic acid RNA RNA sequencing Sequence Analysis, RNA Signatures Skeletal system Stem cells Studies Tendons - cytology Tendons - metabolism Tissue engineering Tissue Engineering - methods Transcription Young Adult
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