The Limonoids TS3 and Rubescin E Induce Apoptosis in Human Hepatoma Cell Lines and Interfere with NF-κB Signaling

Hepatocellular carcinoma (HCC) is extremely resistant towards pharmacological therapy. To date, the multi-kinase inhibitor Sorafenib is the only available therapeutic agent with the potential to prolong patient survival. Using the human hepatoma cell lines HepG2 and Huh7, we analyzed anti-cancer act...

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Veröffentlicht in:	PloS one 2016-08, Vol.11 (8), p.e0160843-e0160843
Hauptverfasser:	Lange, Nicole, Tontsa, Armelle Tsamo, Wegscheid, Claudia, Mkounga, Pierre, Nkengfack, Augustin Ephrem, Loscher, Christine, Sass, Gabriele, Tiegs, Gisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Biology and Life Sciences Biotechnology Cancer Cancer therapies Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell Proliferation - drug effects Cell survival Cell Survival - drug effects Chemical compounds Chromatography Drug Synergism Endangered & extinct species Enzyme inhibitors Hepatocellular carcinoma Hepatology Hepatoma Histone deacetylase Humans Immunology Inhibitors Kinases Limonins - pharmacology Limonoids Liver cancer Liver Neoplasms - pathology Medical research Medicinal plants Medicine and Health Sciences NF-kappa B - metabolism NF-κB protein Niacinamide - analogs & derivatives Niacinamide - pharmacology Organic chemistry Pharmacology Phenylurea Compounds - pharmacology Research and Analysis Methods Signal Transduction - drug effects Signaling Therapy Traditional medicine Trichilia
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