A Public Database of Memory and Naive B-Cell Receptor Sequences
The vast diversity of B-cell receptors (BCR) and secreted antibodies enables the recognition of, and response to, a wide range of epitopes, but this diversity has also limited our understanding of humoral immunity. We present a public database of more than 37 million unique BCR sequences from three...
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| Veröffentlicht in: | PloS one 2016-08, Vol.11 (8), p.e0160853-e0160853 |
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| creator | DeWitt, William S Lindau, Paul Snyder, Thomas M Sherwood, Anna M Vignali, Marissa Carlson, Christopher S Greenberg, Philip D Duerkopp, Natalie Emerson, Ryan O Robins, Harlan S |
| description | The vast diversity of B-cell receptors (BCR) and secreted antibodies enables the recognition of, and response to, a wide range of epitopes, but this diversity has also limited our understanding of humoral immunity. We present a public database of more than 37 million unique BCR sequences from three healthy adult donors that is many fold deeper than any existing resource, together with a set of online tools designed to facilitate the visualization and analysis of the annotated data. We estimate the clonal diversity of the naive and memory B-cell repertoires of healthy individuals, and provide a set of examples that illustrate the utility of the database, including several views of the basic properties of immunoglobulin heavy chain sequences, such as rearrangement length, subunit usage, and somatic hypermutation positions and dynamics. |
| doi_str_mv | 10.1371/journal.pone.0160853 |
| format | Article |
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We present a public database of more than 37 million unique BCR sequences from three healthy adult donors that is many fold deeper than any existing resource, together with a set of online tools designed to facilitate the visualization and analysis of the annotated data. We estimate the clonal diversity of the naive and memory B-cell repertoires of healthy individuals, and provide a set of examples that illustrate the utility of the database, including several views of the basic properties of immunoglobulin heavy chain sequences, such as rearrangement length, subunit usage, and somatic hypermutation positions and dynamics.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0160853</identifier><identifier>PMID: 27513338</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Antibodies ; Antigens ; B cells ; B-cell receptor ; Biology and Life Sciences ; Cancer ; Computer and Information Sciences ; Data bases ; Databases, Factual ; Datasets ; Epitopes ; Genes ; Humans ; Humoral immunity ; Immunity ; Immunity (Physiology) ; Immunity, Humoral ; Immunoglobulins ; Immunologic Memory ; Immunological memory ; Lymphocytes B ; Male ; Management ; Medical research ; Medicine and Health Sciences ; Receptors ; Receptors, Antigen, B-Cell - chemistry ; Research and Analysis Methods ; Somatic hypermutation ; T cell receptors</subject><ispartof>PloS one, 2016-08, Vol.11 (8), p.e0160853-e0160853</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 DeWitt et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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We present a public database of more than 37 million unique BCR sequences from three healthy adult donors that is many fold deeper than any existing resource, together with a set of online tools designed to facilitate the visualization and analysis of the annotated data. 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We present a public database of more than 37 million unique BCR sequences from three healthy adult donors that is many fold deeper than any existing resource, together with a set of online tools designed to facilitate the visualization and analysis of the annotated data. We estimate the clonal diversity of the naive and memory B-cell repertoires of healthy individuals, and provide a set of examples that illustrate the utility of the database, including several views of the basic properties of immunoglobulin heavy chain sequences, such as rearrangement length, subunit usage, and somatic hypermutation positions and dynamics.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27513338</pmid><doi>10.1371/journal.pone.0160853</doi><tpages>e0160853</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Antibodies Antigens B cells B-cell receptor Biology and Life Sciences Cancer Computer and Information Sciences Data bases Databases, Factual Datasets Epitopes Genes Humans Humoral immunity Immunity Immunity (Physiology) Immunity, Humoral Immunoglobulins Immunologic Memory Immunological memory Lymphocytes B Male Management Medical research Medicine and Health Sciences Receptors Receptors, Antigen, B-Cell - chemistry Research and Analysis Methods Somatic hypermutation T cell receptors |
| title | A Public Database of Memory and Naive B-Cell Receptor Sequences |
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