Micro-CT Imaging Reveals Mekk3 Heterozygosity Prevents Cerebral Cavernous Malformations in Ccm2-Deficient Mice

Mutations in CCM1 (aka KRIT1), CCM2, or CCM3 (aka PDCD10) gene cause cerebral cavernous malformation in humans. Mouse models of CCM disease have been established by deleting Ccm genes in postnatal animals. These mouse models provide invaluable tools to investigate molecular mechanism and therapeutic...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2016-08, Vol.11 (8), p.e0160833
Hauptverfasser:	Choi, Jaesung P, Foley, Matthew, Zhou, Zinan, Wong, Weng-Yew, Gokoolparsadh, Naveena, Arthur, J Simon C, Li, Dean Y, Zheng, Xiangjian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal experimentation Animal models Animals Animals, Newborn Biology and Life Sciences Brain research Care and treatment CAT scans CCM2 protein Cerebrovascular diseases Cerebrovascular disorders Computed tomography Diagnosis Disease Disease control Disease Models, Animal Endothelium Female Gene Deletion Health aspects Heterozygosity Heterozygote Hindbrain Histology Humans Intellectual Disability - diagnostic imaging Intellectual Disability - metabolism Intellectual Disability - prevention & control Lesions Male MAP Kinase Kinase Kinase 3 - physiology Medicine Medicine and Health Sciences Methods Mice Mice, Knockout Microfilament Proteins - physiology Micrognathism - diagnostic imaging Micrognathism - metabolism Micrognathism - prevention & control Microscopy Molecular modelling Mutation Neonates Physical Sciences Prevention Research and Analysis Methods Ribs - abnormalities Ribs - diagnostic imaging Ribs - metabolism Rodents Studies Three dimensional imaging Vascular diseases X-Ray Microtomography
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!