The RNA-Binding Protein, Polypyrimidine Tract-Binding Protein 1 (PTBP1) Is a Key Regulator of CD4 T Cell Activation

We have previously shown that the RNA binding protein, polypyrimidine tract-binding protein (PTBP1) plays a critical role in regulating the expression of CD40L in activated CD4 T cells. This is achieved mechanistically through message stabilization at late times of activation as well as by altered d...

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Veröffentlicht in:	PloS one 2016-08, Vol.11 (8), p.e0158708-e0158708
Hauptverfasser:	La Porta, James, Matus-Nicodemos, Rodrigo, Valentín-Acevedo, Aníbal, Covey, Lori R
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Alternative Splicing Antigens Biology Biology and Life Sciences Cancer CD4 antigen CD4 lymphocytes CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD40L protein Cell activation Cell death Cell Proliferation Cells, Cultured Cloning Compartments Cytokines Extracellular signal-regulated kinase Gene expression Heterogeneous-Nuclear Ribonucleoproteins - metabolism Humans Immunology Interleukin 2 Interleukin-2 - metabolism Kinases Lymphocyte Activation Lymphocytes Lymphocytes T Medicine and Health Sciences Metabolism MicroRNAs mRNA Neurosciences NF-kappa B - metabolism NF-κB protein Physiological aspects Polypyrimidine tract-binding protein Polypyrimidine Tract-Binding Protein - metabolism Protein binding Proteins Research and Analysis Methods Ribonucleic acid RNA RNA Stability - genetics RNA Stability - immunology RNA, Messenger - genetics RNA, Messenger - metabolism RNA-binding protein Steady state Transcription activation Tumor necrosis factor-TNF
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