Thrombomodulin Influences the Survival of Patients with Non-Metastatic Colorectal Cancer through Epithelial-To-Mesenchymal Transition (EMT)

Treatment resistance and metastasis are the major causes of death among patients with colorectal cancer (CRC). Approximately 20% of surgically treated patients ultimately develop metastases during the follow-up period. Currently, the TNM system is the only available prognostic test. Therefore, the i...

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Veröffentlicht in:	PloS one 2016-08, Vol.11 (8), p.e0160550-e0160550
Hauptverfasser:	Chang, Yu-Jia, Cheng, Ya-Wen, Lin, Ruo-Kai, Huang, Chi-Chou, Chen, William Tzu-Liang, Ke, Tao-Wei, Wei, Po-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Biological markers Biology and Life Sciences Biomarkers, Tumor - metabolism Biomarkers, Tumor - physiology Biosensors Cancer Care and treatment Cell adhesion & migration Cell migration Cell Movement - genetics Cell proliferation Cell Proliferation - genetics Colon Colon cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - metabolism Colorectal surgery Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Cytoskeleton Disease-Free Survival Engineering and Technology Epithelial-Mesenchymal Transition Ezrin Fibronectin Glycoproteins Health aspects Hospitals Humans Immunohistochemistry Kinases Liver cancer Localization Markers Medical prognosis Medicine Medicine and Health Sciences Mesenchyme Metastases Metastasis Patient outcomes Patients Prognosis Proteins Research and Analysis Methods Rodents Survival Survival Analysis Thrombomodulin Thrombomodulin - genetics Thrombomodulin - metabolism Thrombomodulin - physiology Tissues Treatment resistance Tumor Cells, Cultured Tumors Up-Regulation Vimentin Wound healing
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