DHA but Not EPA Emulsions Preserve Neurological and Mitochondrial Function after Brain Hypoxia-Ischemia in Neonatal Mice

Treatment with triglyceride emulsions of docosahexaenoic acid (tri-DHA) protected neonatal mice against hypoxia-ischemia (HI) brain injury. The mechanism of this neuroprotection remains unclear. We hypothesized that administration of tri-DHA enriches HI-brains with DHA/DHA metabolites. This reduces...

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Veröffentlicht in:	PloS one 2016-08, Vol.11 (8), p.e0160870-e0160870
Hauptverfasser:	Mayurasakorn, Korapat, Niatsetskaya, Zoya V, Sosunov, Sergey A, Williams, Jill J, Zirpoli, Hylde, Vlasakov, Iliyan, Deckelbaum, Richard J, Ten, Vadim S
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Apoptosis Bioactive compounds Biological activity Biology and Life Sciences Brain Brain injuries Brain injury Brain research Buffers Calcium (mitochondrial) Calcium - metabolism Calcium buffering Care and treatment Docosahexaenoic acid Docosahexaenoic Acids - metabolism Docosahexaenoic Acids - therapeutic use Drug dosages Eicosapentaenoic Acid - therapeutic use Emulsions Fatty acid composition Fatty acids Head injuries Health aspects Hyperoxia Hypoxia Hypoxia-Ischemia, Brain - drug therapy Injury prevention Ischemia Lipids Medicine and Health Sciences Metabolites Mice Mice, Inbred C57BL Mitochondria Mitochondria - drug effects Mitochondria - physiology Mitochondrial DNA Neonates Neuroprotection Neuroprotective Agents - therapeutic use Newborn babies Newborn infants Nutrition Omega 3 fatty acids Oxidative Stress - drug effects Oxygen Pediatrics Permeability Reactive oxygen species Reactive Oxygen Species - metabolism Reperfusion Risk factors Rodents Stroke Traumatic brain injury Unsaturated fatty acids
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