Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model
Tumor-targeting Salmonella enterica serovar Typhimurium A1-R (Salmonella A1-R) had strong efficacy on a melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse model. GFP-expressing Salmonella A1-R highly and selectively colonized the PDOX melanoma and significantly suppressed tumor growth (...
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| Veröffentlicht in: | PloS one 2016-08, Vol.11 (8), p.e0160882-e0160882 |
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| creator | Yamamoto, Mako Zhao, Ming Hiroshima, Yukihiko Zhang, Yong Shurell, Elizabeth Eilber, Fritz C Bouvet, Michael Noda, Makoto Hoffman, Robert M |
| description | Tumor-targeting Salmonella enterica serovar Typhimurium A1-R (Salmonella A1-R) had strong efficacy on a melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse model. GFP-expressing Salmonella A1-R highly and selectively colonized the PDOX melanoma and significantly suppressed tumor growth (p = 0.021). The combination of Salmonella A1-R and cisplatinum (CDDP), both at low-dose, also significantly suppressed the growth of the melanoma PDOX (P = 0.001). Salmonella A1-R has future clinical potential for combination chemotherapy with CDDP of melanoma, a highly-recalcitrant cancer. |
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GFP-expressing Salmonella A1-R highly and selectively colonized the PDOX melanoma and significantly suppressed tumor growth (p = 0.021). The combination of Salmonella A1-R and cisplatinum (CDDP), both at low-dose, also significantly suppressed the growth of the melanoma PDOX (P = 0.001). Salmonella A1-R has future clinical potential for combination chemotherapy with CDDP of melanoma, a highly-recalcitrant cancer.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0160882</identifier><identifier>PMID: 27500926</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; Apoptosis ; Biology and Life Sciences ; Cancer ; Cancer therapies ; Cell cycle ; Chemotherapy ; Combination drug therapy ; Combined Modality Therapy ; Consent ; Disease Models, Animal ; Drug therapy ; Humans ; Immunotherapy ; Laboratories ; Medical research ; Medicine and Health Sciences ; Melanoma ; Melanoma - microbiology ; Melanoma - therapy ; Metastasis ; Mice ; Mice, Nude ; Oncology ; Patients ; Research and Analysis Methods ; Resveratrol ; Salmonella ; Salmonella enterica ; Salmonella Infections - microbiology ; Salmonella Typhimurium ; Salmonella typhimurium - growth & development ; Surgery ; Tumors ; Xenograft Model Antitumor Assays ; Xenografts</subject><ispartof>PloS one, 2016-08, Vol.11 (8), p.e0160882-e0160882</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Yamamoto et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Yamamoto et al 2016 Yamamoto et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c736t-35305d16f4fe9e3e2bb43fa65ffdf968b11093ad8d5ba9fe2b04acfee4175c043</citedby><cites>FETCH-LOGICAL-c736t-35305d16f4fe9e3e2bb43fa65ffdf968b11093ad8d5ba9fe2b04acfee4175c043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976963/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976963/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27500926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamamoto, Mako</creatorcontrib><creatorcontrib>Zhao, Ming</creatorcontrib><creatorcontrib>Hiroshima, Yukihiko</creatorcontrib><creatorcontrib>Zhang, Yong</creatorcontrib><creatorcontrib>Shurell, Elizabeth</creatorcontrib><creatorcontrib>Eilber, Fritz C</creatorcontrib><creatorcontrib>Bouvet, Michael</creatorcontrib><creatorcontrib>Noda, Makoto</creatorcontrib><creatorcontrib>Hoffman, Robert M</creatorcontrib><title>Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Tumor-targeting Salmonella enterica serovar Typhimurium A1-R (Salmonella A1-R) had strong efficacy on a melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse model. 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Salmonella A1-R has future clinical potential for combination chemotherapy with CDDP of melanoma, a highly-recalcitrant cancer.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apoptosis</subject><subject>Biology and Life Sciences</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Cell cycle</subject><subject>Chemotherapy</subject><subject>Combination drug therapy</subject><subject>Combined Modality Therapy</subject><subject>Consent</subject><subject>Disease Models, Animal</subject><subject>Drug therapy</subject><subject>Humans</subject><subject>Immunotherapy</subject><subject>Laboratories</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Melanoma</subject><subject>Melanoma - microbiology</subject><subject>Melanoma - therapy</subject><subject>Metastasis</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Oncology</subject><subject>Patients</subject><subject>Research and Analysis Methods</subject><subject>Resveratrol</subject><subject>Salmonella</subject><subject>Salmonella enterica</subject><subject>Salmonella Infections - 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GFP-expressing Salmonella A1-R highly and selectively colonized the PDOX melanoma and significantly suppressed tumor growth (p = 0.021). The combination of Salmonella A1-R and cisplatinum (CDDP), both at low-dose, also significantly suppressed the growth of the melanoma PDOX (P = 0.001). Salmonella A1-R has future clinical potential for combination chemotherapy with CDDP of melanoma, a highly-recalcitrant cancer.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27500926</pmid><doi>10.1371/journal.pone.0160882</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antineoplastic Agents - pharmacology Apoptosis Biology and Life Sciences Cancer Cancer therapies Cell cycle Chemotherapy Combination drug therapy Combined Modality Therapy Consent Disease Models, Animal Drug therapy Humans Immunotherapy Laboratories Medical research Medicine and Health Sciences Melanoma Melanoma - microbiology Melanoma - therapy Metastasis Mice Mice, Nude Oncology Patients Research and Analysis Methods Resveratrol Salmonella Salmonella enterica Salmonella Infections - microbiology Salmonella Typhimurium Salmonella typhimurium - growth & development Surgery Tumors Xenograft Model Antitumor Assays Xenografts |
| title | Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model |
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