What Is a Genome?

The genome is often described as the information repository of an organism. Whether millions or billions of letters of DNA, its transmission across generations confers the principal medium for inheritance of organismal traits. Several emerging areas of research demonstrate that this definition is an...

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Veröffentlicht in:	PLoS genetics 2016-07, Vol.12 (7), p.e1006181-e1006181
Hauptverfasser:	Goldman, Aaron David, Landweber, Laura F
Format:	Artikel
Sprache:	eng
Schlagworte:	Archives & records Biology and Life Sciences Chromosomes Deoxyribonucleic acid DNA Engineering and Technology Evolution, Molecular Funding Genes Genetic research Genome, Protozoan Genomes Handbooks Infections Information sources Methods Oxytricha - genetics Phenotype Research and Analysis Methods Review
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Beschreibung
Zusammenfassung:	The genome is often described as the information repository of an organism. Whether millions or billions of letters of DNA, its transmission across generations confers the principal medium for inheritance of organismal traits. Several emerging areas of research demonstrate that this definition is an oversimplification. Here, we explore ways in which a deeper understanding of genomic diversity and cell physiology is challenging the concepts of physical permanence attached to the genome as well as its role as the sole information source for an organism.
ISSN:	1553-7404 1553-7390 1553-7404
DOI:	10.1371/journal.pgen.1006181