A Computational Modeling and Simulation Approach to Investigate Mechanisms of Subcellular cAMP Compartmentation

Subcellular compartmentation of the ubiquitous second messenger cAMP has been widely proposed as a mechanism to explain unique receptor-dependent functional responses. How exactly compartmentation is achieved, however, has remained a mystery for more than 40 years. In this study, we developed comput...

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Veröffentlicht in:	PLoS computational biology 2016-07, Vol.12 (7), p.e1005005-e1005005
Hauptverfasser:	Yang, Pei-Chi, Boras, Britton W, Jeng, Mao-Tsuen, Docken, Steffen S, Lewis, Timothy J, McCulloch, Andrew D, Harvey, Robert D, Clancy, Colleen E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology and Life Sciences Cells, Cultured Colleges & universities Computational Biology Computer Simulation Cyclic adenosine monophosphate Cyclic AMP - chemistry Cyclic AMP - metabolism Intracellular Space - chemistry Intracellular Space - metabolism Kinases Mathematical models Medicine and Health Sciences Mice Myocytes, Cardiac - chemistry Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Phosphoric Diester Hydrolases - chemistry Phosphoric Diester Hydrolases - metabolism Physical Sciences Physiological aspects Physiology Research and Analysis Methods Signal Transduction - physiology Stochastic models
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