CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection

Mycobacterium tuberculosis (Mtb), possesses at least three type VII secretion systems, ESX-1, -3 and -5 that are actively involved in pathogenesis and host-pathogen interaction. We recently showed that an attenuated Mtb vaccine candidate (Mtb Δppe25-pe19), which lacks the characteristic ESX-5-associ...

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Veröffentlicht in:	PLoS pathogens 2016-07, Vol.12 (7), p.e1005770-e1005770
Hauptverfasser:	Sayes, Fadel, Pawlik, Alexandre, Frigui, Wafa, Gröschel, Matthias I, Crommelynck, Samuel, Fayolle, Catherine, Cia, Felipe, Bancroft, Gregory J, Bottai, Daria, Leclerc, Claude, Brosch, Roland, Majlessi, Laleh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antigens, Bacterial Antigens, Bacterial - immunology Bacterial Proteins Bacterial Proteins - immunology Biology and Life Sciences CD4-Positive T-Lymphocytes CD4-Positive T-Lymphocytes - immunology Cross Reactions Disease Models, Animal Experiments Female Flow Cytometry Immune response Immunization Infections Life Sciences Lymphocytes Medicine and Health Sciences Mice Mice, Inbred C57BL Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Peptides Proteins Th1 Cells Tuberculosis Tuberculosis Vaccines Tuberculosis Vaccines - immunology Tuberculosis, Pulmonary Tuberculosis, Pulmonary - immunology Vaccines
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