Anti-HIV Antibody Responses and the HIV Reservoir Size during Antiretroviral Therapy

A major challenge to HIV eradication strategies is the lack of an accurate measurement of the total burden of replication-competent HIV (the "reservoir"). We assessed the association of anti-HIV antibody responses and the estimated size of the reservoir during antiretroviral therapy (ART)....

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Veröffentlicht in:	PloS one 2016-08, Vol.11 (8), p.e0160192-e0160192
Hauptverfasser:	Lee, Sulggi A, Bacchetti, Peter, Chomont, Nicolas, Fromentin, Remi, Lewin, Sharon R, O'Doherty, Una, Palmer, Sarah, Richman, Douglas D, Siliciano, Janet D, Yukl, Steven A, Deeks, Steven G, Burbelo, Peter D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Anti-HIV agents Anti-HIV Agents - therapeutic use Antigens Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Antiretroviral Therapy, Highly Active Biology and Life Sciences Blood Body burden Care and treatment CD4 antigen CD4 Lymphocyte Count CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology Deoxyribonucleic acid DNA DNA, Viral - drug effects DNA, Viral - genetics Dosage and administration Drug therapy Female Gut-associated lymphoid tissues Health aspects HIV HIV antibodies HIV Antibodies - biosynthesis HIV Antibodies - drug effects HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV Integrase - genetics HIV Integrase - immunology HIV patients HIV-1 - drug effects HIV-1 - genetics HIV-1 - growth & development Human immunodeficiency virus Humans Immunology Immunoprecipitation Infections Infectious diseases Integrase Intestines - drug effects Intestines - immunology Intestines - virology Lentivirus Lymph Nodes - drug effects Lymph Nodes - immunology Lymph Nodes - virology Lymphocytes Lymphocytes T Lymphoid tissue Male Medicine Medicine and Health Sciences Methods Middle Aged Patient outcomes Plasma Polymerase chain reaction Replication Research and Analysis Methods Reservoir sites Ribonucleic acid RNA RNA Splicing RNA, Viral - drug effects RNA, Viral - genetics Statistical analysis Statistical significance Therapy Viral Load - drug effects Viral Load - immunology Virology Viruses
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