Local Intramedullary Delivery of Vancomycin Can Prevent the Development of Long Bone Staphylococcus aureus Infection

Current treatments for methicillin-resistant Staphylococcus aureus (MRSA) infections require intravenously delivered vancomycin; however, systemically delivered vancomycin has its problems. To determine the feasibility and safety of locally delivering vancomycin hydrochloride (~25 mg/Kg) to the medu...

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Veröffentlicht in:	PloS one 2016-07, Vol.11 (7), p.e0160187
Hauptverfasser:	Loc-Carrillo, Catherine, Wang, Caroline, Canden, Ahranee, Burr, Michael, Agarwal, Jayant
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Antibiotics Antimicrobial agents Bacteria Biocompatibility Biology and Life Sciences Biomedical materials Blood plasma Bone and Bones Bones Chemotherapy Chromatography, High Pressure Liquid Complications and side effects Dosage and administration Drug Administration Routes Drug resistance Epidemiology Feasibility studies Health aspects Infections Inoculum Intravenous administration Long bone Low concentrations Male Medicine and Health Sciences Methicillin Methicillin-Resistant Staphylococcus aureus - isolation & purification Muscles Nosocomial infections Osteomyelitis Osteomyelitis - drug therapy Osteomyelitis - microbiology Pharmacokinetics Pharmacology Plastic surgery Prevention Rats Rats, Sprague-Dawley Research and Analysis Methods Risk factors Risk reduction Rodents Staphylococcus aureus Staphylococcus aureus infections Staphylococcus infections Tibia Toxicity Transplants & implants Vancomycin Vancomycin - administration & dosage Vancomycin - pharmacokinetics
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