Genotype-Phenotype Associations of the CD-Associated Single Nucleotide Polymorphism within the Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 22 in Patients of the Swiss IBD Cohort

Protein tyrosine phosphatase non-receptor type 22 (PTPN22) plays an important role in immune cell function and intestinal homeostasis. The single nucleotide polymorphism (SNP) rs2476601 within the PTPN22 gene locus results in aberrant function of PTPN22 protein and protects from Crohn's disease...

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Veröffentlicht in:	PloS one 2016-07, Vol.11 (7), p.e0160215-e0160215
Hauptverfasser:	Spalinger, Marianne R, Zeitz, Jonas, Biedermann, Luc, Rossel, Jean-Benoit, Sulz, Michael C, Frei, Pascal, Scharl, Sylvie, Vavricka, Stephan R, Fried, Michael, Rogler, Gerhard, Scharl, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Adult Alleles Analysis Antibiotics Antibodies Azathioprine Biology and life sciences Calcium Case-Control Studies Cohort Studies Colon Crohn Disease - genetics Crohn's disease Cytokines Female Gastroenterology Gene loci Gene polymorphism Genetic Predisposition to Disease Genotype Genotypes Hepatology Homeostasis Hospitals Humans Immune system Inflammation Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - genetics Inflammatory diseases Intestine Loci Lymphocytes Malabsorption Male Medicine and Health Sciences Nutrient deficiency Patients Phenotype Phosphatase Phosphorylation Physical sciences Physiology Polymorphism Polymorphism, Single Nucleotide Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics Protein-tyrosine-phosphatase Proteins Single nucleotide polymorphisms Single-nucleotide polymorphism Steroid hormones Steroids Studies Switzerland T cell receptors Tumor necrosis factor Tyrosine Ulcerative colitis Vitamin D Young Adult
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