Variation in Human Cytochrome P-450 Drug-Metabolism Genes: A Gateway to the Understanding of Plasmodium vivax Relapses

Although Plasmodium vivax relapses are classically associated with hypnozoite activation, it has been proposed that a proportion of these cases are due to primaquine (PQ) treatment failure caused by polymorphisms in cytochrome P-450 2D6 (CYP2D6). Here, we present evidence that CYP2D6 polymorphisms a...

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Veröffentlicht in:	PloS one 2016-07, Vol.11 (7), p.e0160172-e0160172
Hauptverfasser:	Silvino, Ana Carolina Rios, Costa, Gabriel Luiz, Araújo, Flávia Carolina Faustino de, Ascher, David Benjamin, Pires, Douglas Eduardo Valente, Fontes, Cor Jesus Fernandes, Carvalho, Luzia Helena, Brito, Cristiana Ferreira Alves de, Sousa, Tais Nobrega
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antimalarial agents Antimalarials - metabolism Antimalarials - therapeutic use Bacterial infections Biology and Life Sciences Child Chloroquine Computer applications CYP2D6 protein Cytochrome Cytochrome P-450 Cytochrome P-450 CYP2C8 - genetics Cytochrome P-450 CYP2C8 - metabolism Cytochrome P-450 CYP2D6 - genetics Cytochrome P-450 CYP2D6 - metabolism Cytochrome P450 Drug metabolism Enzymes Failure Female Genes Genetic aspects Genotype Humans Immunology Infections Influence Informatics Malaria Malaria, Vivax - drug therapy Malaria, Vivax - pathology Male Medicine and Health Sciences Metabolism Metabolites Middle Aged Molecular biology Mutation Parasites Pharmacology Physiological aspects Plasmodium vivax Plasmodium vivax - enzymology Plasmodium vivax - genetics Polymorphism, Single Nucleotide Primaquine Primaquine - metabolism Primaquine - therapeutic use Proteins Recurrence Structural stability Young Adult
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