Tissue-Engineered Small Diameter Arterial Vascular Grafts from Cell-Free Nanofiber PCL/Chitosan Scaffolds in a Sheep Model

Tissue engineered vascular grafts (TEVGs) have the potential to overcome the issues faced by existing small diameter prosthetic grafts by providing a biodegradable scaffold where the patient's own cells can engraft and form functional neotissue. However, applying classical approaches to create...

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Veröffentlicht in:	PloS one 2016-07, Vol.11 (7), p.e0158555-e0158555
Hauptverfasser:	Fukunishi, Takuma, Best, Cameron A, Sugiura, Tadahisa, Shoji, Toshihiro, Yi, Tai, Udelsman, Brooks, Ohst, Devan, Ong, Chin Siang, Zhang, Huaitao, Shinoka, Toshiharu, Breuer, Christopher K, Johnson, Jed, Hibino, Narutoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneurysm Animals Aorta Biocompatibility Biodegradability Biodegradation Biology and Life Sciences Biomedical materials Blood Vessel Prosthesis Calcification Cardiovascular disease Care and treatment Carotid artery Cell-Free System Chitosan Chitosan - chemistry Collagen Coronary vessels Degradation Elastin Extracellular Matrix Feasibility studies Grafting Grafts Heart surgery Hydrogels Infiltration Macrophages Mechanical analysis Mechanical properties Medicine and Health Sciences Mice Microscopy, Electron, Scanning Models, Animal Muscle contraction Muscle, Smooth, Vascular - cytology Muscles Nanofibers Nanofibers - chemistry Polycaprolactone Polyesters - chemistry Prostheses Scaffolds Sheep Smooth muscle Stenosis Studies Surgical implants Thromboembolism Thrombosis Tissue Engineering Tissue transplantation Ultrasound Vascular diseases Wall thickness
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