Differential Effectiveness of Clinically-Relevant Analgesics in a Rat Model of Chemotherapy-Induced Mucositis

Chemotherapy-induced intestinal mucositis is characterized by pain and a pro-inflammatory tissue response. Rat models are frequently used in mucositis disease investigations yet little is known about the presence of pain in these animals, the ability of analgesics to ameliorate the condition, or the...

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Veröffentlicht in:	PloS one 2016-07, Vol.11 (7), p.e0158851-e0158851
Hauptverfasser:	Whittaker, Alexandra L, Lymn, Kerry A, Wallace, Georgia L, Howarth, Gordon S
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Analgesics Analgesics - pharmacology Analgesics - therapeutic use Animal models Animals Antineoplastic Agents - adverse effects Behavior, Animal - drug effects Biology and Life Sciences Buprenorphine Cancer therapies Chemotherapy Complications and side effects Cytotoxicity Diagnosis Digestive system Digestive tract Disease Models, Animal Dosage and administration Drug therapy Female Gastrointestinal tract Histology Immune system Inflammation Intestinal Mucosa - drug effects Intestinal Mucosa - enzymology Intestinal Mucosa - pathology Intestine Laboratory animals Mathematical models Medicine and Health Sciences Metabolism Mucositis Mucositis - chemically induced Mucositis - drug therapy Mucositis - pathology Narcotics Opioids Pain Peroxidase Peroxidase - metabolism Rats Risk factors Rodents Tramadol Villus
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