Does Anticoagulant Medication Alter Fracture-Healing? A Morphological and Biomechanical Evaluation of the Possible Effects of Rivaroxaban and Enoxaparin Using a Rat Closed Fracture Model

Low molecular weight heparin (LMWH) is routinely used to prevent thromboembolism in orthopaedic surgery, especially in the treatment of fractures or after joint-replacement. Impairment of fracture-healing due to increased bone-desorption, delayed remodelling and lower calcification caused by direct...

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Veröffentlicht in:	PloS one 2016-07, Vol.11 (7), p.e0159669-e0159669
Hauptverfasser:	Prodinger, Peter Michael, Burgkart, Rainer, Kreutzer, Kilian, Liska, Franz, Pilge, Hakan, Schmitt, Andreas, Knödler, Martina, Holzapfel, Boris Michael, Hapfelmeier, Alexander, Tischer, Thomas, Bissinger, Oliver
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Anisotropy Anticoagulants Anticoagulants - adverse effects Anticoagulants - pharmacology Arthroplasty (hip) Arthroplasty (knee) Biocompatibility Biology and Life Sciences Biomechanical engineering Biomechanical Phenomena - drug effects Biomechanics Biomedical materials Bone density Bone healing Bone mineral content Bone remodeling Bone surgery Bones Calcification Callus Care and treatment Disease Models, Animal Dosage and administration Drugs Embolisms Enoxaparin Enoxaparin - pharmacology Femur Fracture Healing - drug effects Fractures Fractures (Injuries) Fractures, Closed - diagnostic imaging Fractures, Closed - pathology Healing Heparin Heparin, Low-Molecular-Weight - pharmacology Hip Impairment In vivo methods and tests Kinases Knee Low molecular weights Male Mechanical properties Medicine and Health Sciences Molecular weight Morphology Physical Sciences Prevention Rats Rivaroxaban Rivaroxaban - pharmacology Rodents Side effects Surgery Surgical implants Thromboembolism Thrombosis Trauma X-Ray Microtomography
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