Assessment of Risk and Sero-Prevalence of Helicobacter pylori Colonization among Remote Orang Asli Tribes in Peninsula Malaysia
The epidemiology of Helicobacter pylori (H. pylori) infection is related to human poverty with marked differences between developing and developed countries. Socioeconomic factors and living standards are the main determinants of the age-dependent acquisition rate of H. pylori, and consequently its...
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| Veröffentlicht in: | PloS one 2016-07, Vol.11 (7), p.e0159830-e0159830 |
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| creator | Thevakumar, Kavitha Chandren, Josephine Rebecca Perez-Perez, Guillermo Ignacio Chua, Eng Guan Teh, Lay Kek Salleh, Mohd Zaki Tan, Jin Ai Mary Anne Leow, Alex Hwong Ruey Goh, Khean Lee Tay, Alfred Chin Yen Marshall, Barry J Vadivelu, Jamuna Loke, Mun Fai Wong, Li Ping |
| description | The epidemiology of Helicobacter pylori (H. pylori) infection is related to human poverty with marked differences between developing and developed countries. Socioeconomic factors and living standards are the main determinants of the age-dependent acquisition rate of H. pylori, and consequently its prevalence. The aim of this study was to assess the risk and sero-prevalence of H. pylori colonization among Orang Asli in Peninsula Malaysia. This cross-sectional study was conducted on Orang Asli subjects in seven isolated settlements spanning across all three major tribes (Negrito, Proto Malay and Senoi) in Malaysia. Socio-demographic characteristics of the subjects were obtained through interview. Subjects were tested for H. pylori colonization based on CagA and whole cell (WC) antigen serological assays. A total of 275 subjects participated in this study. Among these subjects, 115 (44.7%) were H. pylori sero-positive with highest sero-prevalence among Negrito (65.7%). Among subjects who were H. pylori sero-positive, CagA sero positivity was also significantly higher among Negrito. The highest proportion of respondents reported to be H. pylori sero-positive was from age group 30 years old and below (57.9%), males (56.2%), Negrito (48.6%) and live in bamboo house (92.3%). The highest proportion of respondents reported to be CagA sero-positive was from age group 30 years old and below (41.4%), males (35.6%) and Negrito (48.6%). The results of this study demonstrate that H. pylori colonization can be related to age, gender, tribes and house materials and CagA sero-positive stain closely associated with age, gender and tribes. |
| doi_str_mv | 10.1371/journal.pone.0159830 |
| format | Article |
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Socioeconomic factors and living standards are the main determinants of the age-dependent acquisition rate of H. pylori, and consequently its prevalence. The aim of this study was to assess the risk and sero-prevalence of H. pylori colonization among Orang Asli in Peninsula Malaysia. This cross-sectional study was conducted on Orang Asli subjects in seven isolated settlements spanning across all three major tribes (Negrito, Proto Malay and Senoi) in Malaysia. Socio-demographic characteristics of the subjects were obtained through interview. Subjects were tested for H. pylori colonization based on CagA and whole cell (WC) antigen serological assays. A total of 275 subjects participated in this study. Among these subjects, 115 (44.7%) were H. pylori sero-positive with highest sero-prevalence among Negrito (65.7%). Among subjects who were H. pylori sero-positive, CagA sero positivity was also significantly higher among Negrito. The highest proportion of respondents reported to be H. pylori sero-positive was from age group 30 years old and below (57.9%), males (56.2%), Negrito (48.6%) and live in bamboo house (92.3%). The highest proportion of respondents reported to be CagA sero-positive was from age group 30 years old and below (41.4%), males (35.6%) and Negrito (48.6%). The results of this study demonstrate that H. pylori colonization can be related to age, gender, tribes and house materials and CagA sero-positive stain closely associated with age, gender and tribes.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0159830</identifier><identifier>PMID: 27441568</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Antigens ; Asian Continental Ancestry Group ; Bamboo ; Biology and Life Sciences ; Colonization ; Demographic aspects ; Demographics ; Developed countries ; Economic factors ; Endoscopy ; Epidemiology ; Ethnicity ; Female ; Gastric cancer ; Geography ; Health aspects ; Helicobacter infections ; Helicobacter Infections - diagnosis ; Helicobacter Infections - epidemiology ; Helicobacter Infections - microbiology ; Helicobacter pylori ; Humans ; Hygiene ; Infections ; Infectious diseases ; Laboratories ; Life Style ; Malaysia - epidemiology ; Malaysia - ethnology ; Male ; Males ; Medicine and Health Sciences ; Middle Aged ; Native peoples ; Pathology ; People and Places ; Phenotype ; Population ; Poverty ; Preventive medicine ; Research and Analysis Methods ; Risk Assessment ; Risk factors ; Seroepidemiologic Studies ; Social factors ; Socioeconomic Factors ; Socioeconomics ; Stomach cancer ; Tribes ; Young Adult</subject><ispartof>PloS one, 2016-07, Vol.11 (7), p.e0159830-e0159830</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Thevakumar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Thevakumar et al 2016 Thevakumar et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c791t-cb24662bb8b069c7337d5ecb9282a07be7d089669d1cb6b5ce3bd2435860c49b3</citedby><cites>FETCH-LOGICAL-c791t-cb24662bb8b069c7337d5ecb9282a07be7d089669d1cb6b5ce3bd2435860c49b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956210/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956210/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27441568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thevakumar, Kavitha</creatorcontrib><creatorcontrib>Chandren, Josephine Rebecca</creatorcontrib><creatorcontrib>Perez-Perez, Guillermo Ignacio</creatorcontrib><creatorcontrib>Chua, Eng Guan</creatorcontrib><creatorcontrib>Teh, Lay Kek</creatorcontrib><creatorcontrib>Salleh, Mohd Zaki</creatorcontrib><creatorcontrib>Tan, Jin Ai Mary Anne</creatorcontrib><creatorcontrib>Leow, Alex Hwong Ruey</creatorcontrib><creatorcontrib>Goh, Khean Lee</creatorcontrib><creatorcontrib>Tay, Alfred Chin Yen</creatorcontrib><creatorcontrib>Marshall, Barry J</creatorcontrib><creatorcontrib>Vadivelu, Jamuna</creatorcontrib><creatorcontrib>Loke, Mun Fai</creatorcontrib><creatorcontrib>Wong, Li Ping</creatorcontrib><title>Assessment of Risk and Sero-Prevalence of Helicobacter pylori Colonization among Remote Orang Asli Tribes in Peninsula Malaysia</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The epidemiology of Helicobacter pylori (H. pylori) infection is related to human poverty with marked differences between developing and developed countries. Socioeconomic factors and living standards are the main determinants of the age-dependent acquisition rate of H. pylori, and consequently its prevalence. The aim of this study was to assess the risk and sero-prevalence of H. pylori colonization among Orang Asli in Peninsula Malaysia. This cross-sectional study was conducted on Orang Asli subjects in seven isolated settlements spanning across all three major tribes (Negrito, Proto Malay and Senoi) in Malaysia. Socio-demographic characteristics of the subjects were obtained through interview. Subjects were tested for H. pylori colonization based on CagA and whole cell (WC) antigen serological assays. A total of 275 subjects participated in this study. Among these subjects, 115 (44.7%) were H. pylori sero-positive with highest sero-prevalence among Negrito (65.7%). Among subjects who were H. pylori sero-positive, CagA sero positivity was also significantly higher among Negrito. The highest proportion of respondents reported to be H. pylori sero-positive was from age group 30 years old and below (57.9%), males (56.2%), Negrito (48.6%) and live in bamboo house (92.3%). The highest proportion of respondents reported to be CagA sero-positive was from age group 30 years old and below (41.4%), males (35.6%) and Negrito (48.6%). The results of this study demonstrate that H. pylori colonization can be related to age, gender, tribes and house materials and CagA sero-positive stain closely associated with age, gender and tribes.</description><subject>Adult</subject><subject>Age</subject><subject>Antigens</subject><subject>Asian Continental Ancestry Group</subject><subject>Bamboo</subject><subject>Biology and Life Sciences</subject><subject>Colonization</subject><subject>Demographic aspects</subject><subject>Demographics</subject><subject>Developed countries</subject><subject>Economic factors</subject><subject>Endoscopy</subject><subject>Epidemiology</subject><subject>Ethnicity</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Geography</subject><subject>Health aspects</subject><subject>Helicobacter infections</subject><subject>Helicobacter Infections - diagnosis</subject><subject>Helicobacter Infections - epidemiology</subject><subject>Helicobacter Infections - 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Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thevakumar, Kavitha</au><au>Chandren, Josephine Rebecca</au><au>Perez-Perez, Guillermo Ignacio</au><au>Chua, Eng Guan</au><au>Teh, Lay Kek</au><au>Salleh, Mohd Zaki</au><au>Tan, Jin Ai Mary Anne</au><au>Leow, Alex Hwong Ruey</au><au>Goh, Khean Lee</au><au>Tay, Alfred Chin Yen</au><au>Marshall, Barry J</au><au>Vadivelu, Jamuna</au><au>Loke, Mun Fai</au><au>Wong, Li Ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of Risk and Sero-Prevalence of Helicobacter pylori Colonization among Remote Orang Asli Tribes in Peninsula Malaysia</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-07-21</date><risdate>2016</risdate><volume>11</volume><issue>7</issue><spage>e0159830</spage><epage>e0159830</epage><pages>e0159830-e0159830</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The epidemiology of Helicobacter pylori (H. pylori) infection is related to human poverty with marked differences between developing and developed countries. Socioeconomic factors and living standards are the main determinants of the age-dependent acquisition rate of H. pylori, and consequently its prevalence. The aim of this study was to assess the risk and sero-prevalence of H. pylori colonization among Orang Asli in Peninsula Malaysia. This cross-sectional study was conducted on Orang Asli subjects in seven isolated settlements spanning across all three major tribes (Negrito, Proto Malay and Senoi) in Malaysia. Socio-demographic characteristics of the subjects were obtained through interview. Subjects were tested for H. pylori colonization based on CagA and whole cell (WC) antigen serological assays. A total of 275 subjects participated in this study. Among these subjects, 115 (44.7%) were H. pylori sero-positive with highest sero-prevalence among Negrito (65.7%). Among subjects who were H. pylori sero-positive, CagA sero positivity was also significantly higher among Negrito. The highest proportion of respondents reported to be H. pylori sero-positive was from age group 30 years old and below (57.9%), males (56.2%), Negrito (48.6%) and live in bamboo house (92.3%). The highest proportion of respondents reported to be CagA sero-positive was from age group 30 years old and below (41.4%), males (35.6%) and Negrito (48.6%). The results of this study demonstrate that H. pylori colonization can be related to age, gender, tribes and house materials and CagA sero-positive stain closely associated with age, gender and tribes.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27441568</pmid><doi>10.1371/journal.pone.0159830</doi><tpages>e0159830</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-07, Vol.11 (7), p.e0159830-e0159830 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1806087057 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Age Antigens Asian Continental Ancestry Group Bamboo Biology and Life Sciences Colonization Demographic aspects Demographics Developed countries Economic factors Endoscopy Epidemiology Ethnicity Female Gastric cancer Geography Health aspects Helicobacter infections Helicobacter Infections - diagnosis Helicobacter Infections - epidemiology Helicobacter Infections - microbiology Helicobacter pylori Humans Hygiene Infections Infectious diseases Laboratories Life Style Malaysia - epidemiology Malaysia - ethnology Male Males Medicine and Health Sciences Middle Aged Native peoples Pathology People and Places Phenotype Population Poverty Preventive medicine Research and Analysis Methods Risk Assessment Risk factors Seroepidemiologic Studies Social factors Socioeconomic Factors Socioeconomics Stomach cancer Tribes Young Adult |
| title | Assessment of Risk and Sero-Prevalence of Helicobacter pylori Colonization among Remote Orang Asli Tribes in Peninsula Malaysia |
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