Conducting Precision Medicine Research with African Americans
Precision medicine is an approach to detecting, treating, and managing disease that is based on individual variation in genetic, environmental, and lifestyle factors. Precision medicine is expected to reduce health disparities, but this will be possible only if studies have adequate representation o...
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description | Precision medicine is an approach to detecting, treating, and managing disease that is based on individual variation in genetic, environmental, and lifestyle factors. Precision medicine is expected to reduce health disparities, but this will be possible only if studies have adequate representation of racial minorities.
It is critical to anticipate the rates at which individuals from diverse populations are likely to participate in precision medicine studies as research initiatives are being developed. We evaluated the likelihood of participating in a clinical study for precision medicine.
Observational study conducted between October 2010 and February 2011 in a national sample of African Americans.
Intentions to participate in a government sponsored study that involves providing a biospecimen and generates data that could be shared with other researchers to conduct future studies.
One third of respondents would participate in a clinical study for precision medicine. Only gender had a significant independent association with participation intentions. Men had a 1.86 (95% CI = 1.11, 3.12, p = 0.02) increased likelihood of participating in a precision medicine study compared to women in the model that included overall barriers and facilitators. In the model with specific participation barriers, distrust was associated with a reduced likelihood of participating in the research described in the vignette (OR = 0.57, 95% CI = 0.34, 0.96, p = 0.04).
African Americans may have low enrollment in PMI research. As PMI research is implemented, extensive efforts will be needed to ensure adequate representation. Additional research is needed to identify optimal ways of ethically describing precision medicine studies to ensure sufficient recruitment of racial minorities. |
doi_str_mv | 10.1371/journal.pone.0154850 |
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It is critical to anticipate the rates at which individuals from diverse populations are likely to participate in precision medicine studies as research initiatives are being developed. We evaluated the likelihood of participating in a clinical study for precision medicine.
Observational study conducted between October 2010 and February 2011 in a national sample of African Americans.
Intentions to participate in a government sponsored study that involves providing a biospecimen and generates data that could be shared with other researchers to conduct future studies.
One third of respondents would participate in a clinical study for precision medicine. Only gender had a significant independent association with participation intentions. Men had a 1.86 (95% CI = 1.11, 3.12, p = 0.02) increased likelihood of participating in a precision medicine study compared to women in the model that included overall barriers and facilitators. In the model with specific participation barriers, distrust was associated with a reduced likelihood of participating in the research described in the vignette (OR = 0.57, 95% CI = 0.34, 0.96, p = 0.04).
African Americans may have low enrollment in PMI research. As PMI research is implemented, extensive efforts will be needed to ensure adequate representation. Additional research is needed to identify optimal ways of ethically describing precision medicine studies to ensure sufficient recruitment of racial minorities.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0154850</identifier><identifier>PMID: 27441706</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>African Americans ; Analysis ; Biology and Life Sciences ; Biomedical Research ; Disease control ; Ethical standards ; Genetic diversity ; Genome-wide association studies ; Health aspects ; Humans ; Logistic Models ; Medicine ; Medicine and Health Sciences ; Minority & ethnic groups ; Multiculturalism & pluralism ; Multivariate Analysis ; People and places ; Precision Medicine ; R&D ; Recruitment ; Representations ; Research & development ; Research and Analysis Methods ; Studies</subject><ispartof>PloS one, 2016-07, Vol.11 (7), p.e0154850</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-e45bebe226f0b90735c57841c63a1333430713f26d42fbb3fe82154907ad33703</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956119/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956119/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27441706$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chiba-Falek, Ornit</contributor><creatorcontrib>Halbert, Chanita Hughes</creatorcontrib><creatorcontrib>McDonald, Jasmine</creatorcontrib><creatorcontrib>Vadaparampil, Susan</creatorcontrib><creatorcontrib>Rice, LaShanta</creatorcontrib><creatorcontrib>Jefferson, Melanie</creatorcontrib><title>Conducting Precision Medicine Research with African Americans</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Precision medicine is an approach to detecting, treating, and managing disease that is based on individual variation in genetic, environmental, and lifestyle factors. Precision medicine is expected to reduce health disparities, but this will be possible only if studies have adequate representation of racial minorities.
It is critical to anticipate the rates at which individuals from diverse populations are likely to participate in precision medicine studies as research initiatives are being developed. We evaluated the likelihood of participating in a clinical study for precision medicine.
Observational study conducted between October 2010 and February 2011 in a national sample of African Americans.
Intentions to participate in a government sponsored study that involves providing a biospecimen and generates data that could be shared with other researchers to conduct future studies.
One third of respondents would participate in a clinical study for precision medicine. Only gender had a significant independent association with participation intentions. Men had a 1.86 (95% CI = 1.11, 3.12, p = 0.02) increased likelihood of participating in a precision medicine study compared to women in the model that included overall barriers and facilitators. In the model with specific participation barriers, distrust was associated with a reduced likelihood of participating in the research described in the vignette (OR = 0.57, 95% CI = 0.34, 0.96, p = 0.04).
African Americans may have low enrollment in PMI research. As PMI research is implemented, extensive efforts will be needed to ensure adequate representation. Additional research is needed to identify optimal ways of ethically describing precision medicine studies to ensure sufficient recruitment of racial minorities.</description><subject>African Americans</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Biomedical Research</subject><subject>Disease control</subject><subject>Ethical standards</subject><subject>Genetic diversity</subject><subject>Genome-wide association studies</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Minority & ethnic groups</subject><subject>Multiculturalism & pluralism</subject><subject>Multivariate Analysis</subject><subject>People and places</subject><subject>Precision Medicine</subject><subject>R&D</subject><subject>Recruitment</subject><subject>Representations</subject><subject>Research & development</subject><subject>Research and 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(Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Halbert, Chanita Hughes</au><au>McDonald, Jasmine</au><au>Vadaparampil, Susan</au><au>Rice, LaShanta</au><au>Jefferson, Melanie</au><au>Chiba-Falek, Ornit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conducting Precision Medicine Research with African Americans</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-07-21</date><risdate>2016</risdate><volume>11</volume><issue>7</issue><spage>e0154850</spage><pages>e0154850-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Precision medicine is an approach to detecting, treating, and managing disease that is based on individual variation in genetic, environmental, and lifestyle factors. Precision medicine is expected to reduce health disparities, but this will be possible only if studies have adequate representation of racial minorities.
It is critical to anticipate the rates at which individuals from diverse populations are likely to participate in precision medicine studies as research initiatives are being developed. We evaluated the likelihood of participating in a clinical study for precision medicine.
Observational study conducted between October 2010 and February 2011 in a national sample of African Americans.
Intentions to participate in a government sponsored study that involves providing a biospecimen and generates data that could be shared with other researchers to conduct future studies.
One third of respondents would participate in a clinical study for precision medicine. Only gender had a significant independent association with participation intentions. Men had a 1.86 (95% CI = 1.11, 3.12, p = 0.02) increased likelihood of participating in a precision medicine study compared to women in the model that included overall barriers and facilitators. In the model with specific participation barriers, distrust was associated with a reduced likelihood of participating in the research described in the vignette (OR = 0.57, 95% CI = 0.34, 0.96, p = 0.04).
African Americans may have low enrollment in PMI research. As PMI research is implemented, extensive efforts will be needed to ensure adequate representation. Additional research is needed to identify optimal ways of ethically describing precision medicine studies to ensure sufficient recruitment of racial minorities.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27441706</pmid><doi>10.1371/journal.pone.0154850</doi><tpages>e0154850</tpages><oa>free_for_read</oa></addata></record> |
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subjects | African Americans Analysis Biology and Life Sciences Biomedical Research Disease control Ethical standards Genetic diversity Genome-wide association studies Health aspects Humans Logistic Models Medicine Medicine and Health Sciences Minority & ethnic groups Multiculturalism & pluralism Multivariate Analysis People and places Precision Medicine R&D Recruitment Representations Research & development Research and Analysis Methods Studies |
title | Conducting Precision Medicine Research with African Americans |
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