Conducting Precision Medicine Research with African Americans

Precision medicine is an approach to detecting, treating, and managing disease that is based on individual variation in genetic, environmental, and lifestyle factors. Precision medicine is expected to reduce health disparities, but this will be possible only if studies have adequate representation o...

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Veröffentlicht in:PloS one 2016-07, Vol.11 (7), p.e0154850
Hauptverfasser: Halbert, Chanita Hughes, McDonald, Jasmine, Vadaparampil, Susan, Rice, LaShanta, Jefferson, Melanie
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creator Halbert, Chanita Hughes
McDonald, Jasmine
Vadaparampil, Susan
Rice, LaShanta
Jefferson, Melanie
description Precision medicine is an approach to detecting, treating, and managing disease that is based on individual variation in genetic, environmental, and lifestyle factors. Precision medicine is expected to reduce health disparities, but this will be possible only if studies have adequate representation of racial minorities. It is critical to anticipate the rates at which individuals from diverse populations are likely to participate in precision medicine studies as research initiatives are being developed. We evaluated the likelihood of participating in a clinical study for precision medicine. Observational study conducted between October 2010 and February 2011 in a national sample of African Americans. Intentions to participate in a government sponsored study that involves providing a biospecimen and generates data that could be shared with other researchers to conduct future studies. One third of respondents would participate in a clinical study for precision medicine. Only gender had a significant independent association with participation intentions. Men had a 1.86 (95% CI = 1.11, 3.12, p = 0.02) increased likelihood of participating in a precision medicine study compared to women in the model that included overall barriers and facilitators. In the model with specific participation barriers, distrust was associated with a reduced likelihood of participating in the research described in the vignette (OR = 0.57, 95% CI = 0.34, 0.96, p = 0.04). African Americans may have low enrollment in PMI research. As PMI research is implemented, extensive efforts will be needed to ensure adequate representation. Additional research is needed to identify optimal ways of ethically describing precision medicine studies to ensure sufficient recruitment of racial minorities.
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subjects African Americans
Analysis
Biology and Life Sciences
Biomedical Research
Disease control
Ethical standards
Genetic diversity
Genome-wide association studies
Health aspects
Humans
Logistic Models
Medicine
Medicine and Health Sciences
Minority & ethnic groups
Multiculturalism & pluralism
Multivariate Analysis
People and places
Precision Medicine
R&D
Recruitment
Representations
Research & development
Research and Analysis Methods
Studies
title Conducting Precision Medicine Research with African Americans
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