Feasibility of Human Amniotic Fluid Derived Stem Cells in Alleviation of Neuropathic Pain in Chronic Constrictive Injury Nerve Model

The neurobehavior of neuropathic pain by chronic constriction injury (CCI) of sciatic nerve is very similar to that in humans, and it is accompanied by a profound local inflammation response. In this study, we assess the potentiality of human amniotic fluid derived mesenchymal stem cells (hAFMSCs) f...

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Veröffentlicht in:	PloS one 2016-07, Vol.11 (7), p.e0159482-e0159482
Hauptverfasser:	Chiang, Chien-Yi, Liu, Shih-An, Sheu, Meei-Ling, Chen, Fu-Chou, Chen, Chun-Jung, Su, Hong-Lin, Pan, Hung-Chuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amniotic fluid Amniotic Fluid - cytology Animals Attenuation Behavior Behavior, Animal Biology and Life Sciences Care and treatment Cell culture Cells, Cultured Chronic Disease Constriction Disease Models, Animal Dorsal root ganglia Evoked Potentials, Somatosensory Experiments Feasibility Studies Gait Gene expression Hospitals Humans Hyperalgesia - complications Hyperalgesia - pathology Hyperalgesia - physiopathology Hyperalgesia - therapy IL-1β Inflammation Inflammation - complications Inflammation - pathology Inflammatory response Injuries Interleukin-1beta - metabolism Intravenous administration Medical research Medicine Medicine and Health Sciences Mesenchymal stem cells Mesenchyme Nerve Regeneration Nervous system Neuralgia Neuralgia - complications Neuralgia - pathology Neuralgia - physiopathology Neuralgia - therapy Neuropathy Neurosciences Pain Pain perception Rats Rats, Sprague-Dawley Risk factors Rodents Sciatic nerve Sciatic Nerve - pathology Sciatic Nerve - physiopathology Skin Spinal cord Stem Cell Transplantation Stem cells Stem Cells - cytology Studies Synaptophysin Synaptophysin - metabolism Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α Ubiquitin Thiolesterase - metabolism
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