Diffusive Silicon Nanopore Membranes for Hemodialysis Applications
Hemodialysis using hollow-fiber membranes provides life-sustaining treatment for nearly 2 million patients worldwide with end stage renal disease (ESRD). However, patients on hemodialysis have worse long-term outcomes compared to kidney transplant or other chronic illnesses. Additionally, the underl...
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| creator | Kim, Steven Feinberg, Benjamin Kant, Rishi Chui, Benjamin Goldman, Ken Park, Jaehyun Moses, Willieford Blaha, Charles Iqbal, Zohora Chow, Clarence Wright, Nathan Fissell, William H Zydney, Andrew Roy, Shuvo |
| description | Hemodialysis using hollow-fiber membranes provides life-sustaining treatment for nearly 2 million patients worldwide with end stage renal disease (ESRD). However, patients on hemodialysis have worse long-term outcomes compared to kidney transplant or other chronic illnesses. Additionally, the underlying membrane technology of polymer hollow-fiber membranes has not fundamentally changed in over four decades. Therefore, we have proposed a fundamentally different approach using microelectromechanical systems (MEMS) fabrication techniques to create thin-flat sheets of silicon-based membranes for implantable or portable hemodialysis applications. The silicon nanopore membranes (SNM) have biomimetic slit-pore geometry and uniform pores size distribution that allow for exceptional permeability and selectivity. A quantitative diffusion model identified structural limits to diffusive solute transport and motivated a new microfabrication technique to create SNM with enhanced diffusive transport. We performed in vitro testing and extracorporeal testing in pigs on prototype membranes with an effective surface area of 2.52 cm2 and 2.02 cm2, respectively. The diffusive clearance was a two-fold improvement in with the new microfabrication technique and was consistent with our mathematical model. These results establish the feasibility of using SNM for hemodialysis applications with additional scale-up. |
| doi_str_mv | 10.1371/journal.pone.0159526 |
| format | Article |
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However, patients on hemodialysis have worse long-term outcomes compared to kidney transplant or other chronic illnesses. Additionally, the underlying membrane technology of polymer hollow-fiber membranes has not fundamentally changed in over four decades. Therefore, we have proposed a fundamentally different approach using microelectromechanical systems (MEMS) fabrication techniques to create thin-flat sheets of silicon-based membranes for implantable or portable hemodialysis applications. The silicon nanopore membranes (SNM) have biomimetic slit-pore geometry and uniform pores size distribution that allow for exceptional permeability and selectivity. A quantitative diffusion model identified structural limits to diffusive solute transport and motivated a new microfabrication technique to create SNM with enhanced diffusive transport. We performed in vitro testing and extracorporeal testing in pigs on prototype membranes with an effective surface area of 2.52 cm2 and 2.02 cm2, respectively. The diffusive clearance was a two-fold improvement in with the new microfabrication technique and was consistent with our mathematical model. These results establish the feasibility of using SNM for hemodialysis applications with additional scale-up.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0159526</identifier><identifier>PMID: 27438878</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Addition polymerization ; Analysis ; Animals ; Biology and Life Sciences ; Biomimetics ; Blood platelets ; Care and treatment ; Chronic illnesses ; Chronic kidney failure ; Diagnosis ; Dialysis ; Diffusion ; Diffusion models ; Fabrication ; Feasibility studies ; Geometry ; Health aspects ; Hemodialysis ; Hollow fiber membranes ; Humans ; Illnesses ; In vitro methods and tests ; Innovations ; Kidney Failure, Chronic - physiopathology ; Kidney Failure, Chronic - therapy ; Kidney transplantation ; Mathematical models ; Mathematics ; Medicine and Health Sciences ; Membrane filters ; Membrane permeability ; Membranes ; Membranes, Artificial ; Microelectromechanical systems ; Mortality ; Nanopores ; Nanostructured materials ; Oxidative stress ; Patient outcomes ; Patients ; Peritoneal dialysis ; Permeability ; Physical Sciences ; Polymers ; Polymers - chemistry ; Polymers - therapeutic use ; Porosity ; Properties ; Renal Dialysis - methods ; Silicon ; Silicon - chemistry ; Silicon - therapeutic use ; Size distribution ; Solute transport ; Solutions - chemistry ; Swine ; Transplants & implants ; Transport</subject><ispartof>PloS one, 2016-07, Vol.11 (7), p.e0159526</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Kim et al 2016 Kim et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-c851824adad9a444020df96677e4421405f55db24f2524e6985dfe6fb3a592743</citedby><cites>FETCH-LOGICAL-c725t-c851824adad9a444020df96677e4421405f55db24f2524e6985dfe6fb3a592743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954641/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954641/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27438878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Joles, Jaap A.</contributor><creatorcontrib>Kim, Steven</creatorcontrib><creatorcontrib>Feinberg, Benjamin</creatorcontrib><creatorcontrib>Kant, Rishi</creatorcontrib><creatorcontrib>Chui, Benjamin</creatorcontrib><creatorcontrib>Goldman, Ken</creatorcontrib><creatorcontrib>Park, Jaehyun</creatorcontrib><creatorcontrib>Moses, Willieford</creatorcontrib><creatorcontrib>Blaha, Charles</creatorcontrib><creatorcontrib>Iqbal, Zohora</creatorcontrib><creatorcontrib>Chow, Clarence</creatorcontrib><creatorcontrib>Wright, Nathan</creatorcontrib><creatorcontrib>Fissell, William H</creatorcontrib><creatorcontrib>Zydney, Andrew</creatorcontrib><creatorcontrib>Roy, Shuvo</creatorcontrib><title>Diffusive Silicon Nanopore Membranes for Hemodialysis Applications</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Hemodialysis using hollow-fiber membranes provides life-sustaining treatment for nearly 2 million patients worldwide with end stage renal disease (ESRD). However, patients on hemodialysis have worse long-term outcomes compared to kidney transplant or other chronic illnesses. Additionally, the underlying membrane technology of polymer hollow-fiber membranes has not fundamentally changed in over four decades. Therefore, we have proposed a fundamentally different approach using microelectromechanical systems (MEMS) fabrication techniques to create thin-flat sheets of silicon-based membranes for implantable or portable hemodialysis applications. The silicon nanopore membranes (SNM) have biomimetic slit-pore geometry and uniform pores size distribution that allow for exceptional permeability and selectivity. A quantitative diffusion model identified structural limits to diffusive solute transport and motivated a new microfabrication technique to create SNM with enhanced diffusive transport. 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These results establish the feasibility of using SNM for hemodialysis applications with additional scale-up.</description><subject>Addition polymerization</subject><subject>Analysis</subject><subject>Animals</subject><subject>Biology and Life Sciences</subject><subject>Biomimetics</subject><subject>Blood platelets</subject><subject>Care and treatment</subject><subject>Chronic illnesses</subject><subject>Chronic kidney failure</subject><subject>Diagnosis</subject><subject>Dialysis</subject><subject>Diffusion</subject><subject>Diffusion models</subject><subject>Fabrication</subject><subject>Feasibility studies</subject><subject>Geometry</subject><subject>Health aspects</subject><subject>Hemodialysis</subject><subject>Hollow fiber membranes</subject><subject>Humans</subject><subject>Illnesses</subject><subject>In vitro methods and tests</subject><subject>Innovations</subject><subject>Kidney Failure, Chronic - physiopathology</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Kidney transplantation</subject><subject>Mathematical models</subject><subject>Mathematics</subject><subject>Medicine and Health Sciences</subject><subject>Membrane filters</subject><subject>Membrane permeability</subject><subject>Membranes</subject><subject>Membranes, Artificial</subject><subject>Microelectromechanical systems</subject><subject>Mortality</subject><subject>Nanopores</subject><subject>Nanostructured materials</subject><subject>Oxidative stress</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Peritoneal dialysis</subject><subject>Permeability</subject><subject>Physical Sciences</subject><subject>Polymers</subject><subject>Polymers - chemistry</subject><subject>Polymers - therapeutic use</subject><subject>Porosity</subject><subject>Properties</subject><subject>Renal Dialysis - methods</subject><subject>Silicon</subject><subject>Silicon - chemistry</subject><subject>Silicon - therapeutic use</subject><subject>Size distribution</subject><subject>Solute transport</subject><subject>Solutions - chemistry</subject><subject>Swine</subject><subject>Transplants & 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Silicon Nanopore Membranes for Hemodialysis Applications</title><author>Kim, Steven ; Feinberg, Benjamin ; Kant, Rishi ; Chui, Benjamin ; Goldman, Ken ; Park, Jaehyun ; Moses, Willieford ; Blaha, Charles ; Iqbal, Zohora ; Chow, Clarence ; Wright, Nathan ; Fissell, William H ; Zydney, Andrew ; Roy, Shuvo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c725t-c851824adad9a444020df96677e4421405f55db24f2524e6985dfe6fb3a592743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Addition polymerization</topic><topic>Analysis</topic><topic>Animals</topic><topic>Biology and Life Sciences</topic><topic>Biomimetics</topic><topic>Blood platelets</topic><topic>Care and treatment</topic><topic>Chronic illnesses</topic><topic>Chronic kidney failure</topic><topic>Diagnosis</topic><topic>Dialysis</topic><topic>Diffusion</topic><topic>Diffusion 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However, patients on hemodialysis have worse long-term outcomes compared to kidney transplant or other chronic illnesses. Additionally, the underlying membrane technology of polymer hollow-fiber membranes has not fundamentally changed in over four decades. Therefore, we have proposed a fundamentally different approach using microelectromechanical systems (MEMS) fabrication techniques to create thin-flat sheets of silicon-based membranes for implantable or portable hemodialysis applications. The silicon nanopore membranes (SNM) have biomimetic slit-pore geometry and uniform pores size distribution that allow for exceptional permeability and selectivity. A quantitative diffusion model identified structural limits to diffusive solute transport and motivated a new microfabrication technique to create SNM with enhanced diffusive transport. 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| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-07, Vol.11 (7), p.e0159526 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1805757206 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Addition polymerization Analysis Animals Biology and Life Sciences Biomimetics Blood platelets Care and treatment Chronic illnesses Chronic kidney failure Diagnosis Dialysis Diffusion Diffusion models Fabrication Feasibility studies Geometry Health aspects Hemodialysis Hollow fiber membranes Humans Illnesses In vitro methods and tests Innovations Kidney Failure, Chronic - physiopathology Kidney Failure, Chronic - therapy Kidney transplantation Mathematical models Mathematics Medicine and Health Sciences Membrane filters Membrane permeability Membranes Membranes, Artificial Microelectromechanical systems Mortality Nanopores Nanostructured materials Oxidative stress Patient outcomes Patients Peritoneal dialysis Permeability Physical Sciences Polymers Polymers - chemistry Polymers - therapeutic use Porosity Properties Renal Dialysis - methods Silicon Silicon - chemistry Silicon - therapeutic use Size distribution Solute transport Solutions - chemistry Swine Transplants & implants Transport |
| title | Diffusive Silicon Nanopore Membranes for Hemodialysis Applications |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T12%3A27%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Diffusive%20Silicon%20Nanopore%20Membranes%20for%20Hemodialysis%20Applications&rft.jtitle=PloS%20one&rft.au=Kim,%20Steven&rft.date=2016-07-20&rft.volume=11&rft.issue=7&rft.spage=e0159526&rft.pages=e0159526-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0159526&rft_dat=%3Cgale_plos_%3EA458869451%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1805757206&rft_id=info:pmid/27438878&rft_galeid=A458869451&rft_doaj_id=oai_doaj_org_article_08c7dfe9101e486091b9624dd9065613&rfr_iscdi=true |